Outcomes of lung-surgery patients suffered perioperative COVID-19: A systematic review of case reports and case series

ABSTRACT

Coronavirus disease 2019 has spread widely all over the world since December 2019.It is known that lung is mainly targeting organ of the disease. however, outcome of lung-surgery patients who suffered Coronavirus disease 2019 remains unclear. We comprehensively searched PubMed, Ovid and Web of Science for studies on Coronavirus disease 2019 and lung surgery by January 11, 2020. Then we meticulously collected information including survival information, demographics, surgery information, pathological data, comorbidity, symptoms, treatment and other detailed data. Cases were divided into survival group and death group for analysis, multivariate logistic regression analysis were further applied to assess prognostic predictors. A total of 20 studies including 52 patients were finally enrolled in this study, 36 patients were successfully discharged while 16 patients died even after treatment, mortality reached 30.77%. Of all the cases, a total of 10 patients were suffered Coronavirus disease 2019 before surgery and 3 patients died postoperatively, totally 42 patients were infected Coronavirus disease 2019 postoperatively and 13 patients died. Though mortality differences existed concerning several variables in different degree, no statistical significances were found concerning all variables in different level analysis. Total mortality of lung-surgery patients suffered perioperatively Coronavirus disease 2019 was 30.77%, while mortality of preoperative Coronavirus disease 2019 infection and postoperative Coronavirus disease 2019 infection reached 30% and 30.95%, respectively.