COVID-19-Associated Critical Illness Myopathy with Direct Viral Effects.
Ann Neurol
; 91(4): 568-574, 2022 04.
Article
in English
| MEDLINE | ID: covidwho-1680263
ABSTRACT
Coronavirus disease 2019 (COVID-19) severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2 infection) can lead to intensive care unit (ICU) admission and critical illness myopathy (CIM). We examined 3 ICU patients with COVID-19 who required mechanical ventilation for pneumonia and developed CIM. Pathological examination of the skeletal muscle biopsies revealed myopathic changes consistent with CIM, variable inflammation with autophagic vacuoles, SARS-CoV immunostaining + fibers/granules, and electron microscopy findings of mitochondrial abnormalities and coronavirus-like particles. Although mitochondrial dysfunction with compromised energy production is a critical pathogenic mechanism of non-COVID-19-associated CIM, in our series of COVID-19-associated CIM, myopathic changes including prominent mitochondrial damage suggest a similar mechanism and association with direct SARS-CoV-2 muscle infection. ANN NEUROL 2022;91568-574.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Critical Illness
/
SARS-CoV-2
/
COVID-19
/
Muscular Diseases
Type of study:
Case report
/
Experimental Studies
/
Prognostic study
Topics:
Long Covid
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Ann Neurol
Year:
2022
Document Type:
Article
Affiliation country:
Ana.26318
Similar
MEDLINE
...
LILACS
LIS