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Potential of the CRISPR-Cas system for improved parasite diagnosis: CRISPR-Cas mediated diagnosis in parasitic infections: CRISPR-Cas mediated diagnosis in parasitic infections.
You, Hong; Gordon, Catherine A; MacGregor, Skye R; Cai, Pengfei; McManus, Donald P.
  • You H; Immunology Department, QIMR Berghofer Medical Research Institute, Queensland, Australia.
  • Gordon CA; Immunology Department, QIMR Berghofer Medical Research Institute, Queensland, Australia.
  • MacGregor SR; Immunology Department, QIMR Berghofer Medical Research Institute, Queensland, Australia.
  • Cai P; Immunology Department, QIMR Berghofer Medical Research Institute, Queensland, Australia.
  • McManus DP; Immunology Department, QIMR Berghofer Medical Research Institute, Queensland, Australia.
Bioessays ; 44(4): e2100286, 2022 04.
Article in English | MEDLINE | ID: covidwho-1680275
ABSTRACT
CRISPR-Cas technology accelerates development of fast, accurate, and portable diagnostic tools, typified by recent applications in COVID-19 diagnosis. Parasitic helminths cause devastating diseases afflicting 1.5 billion people globally, representing a significant public health and economic burden, especially in developing countries. Currently available diagnostic tests for worm infection are neither sufficiently sensitive nor field-friendly for use in low-endemic or resource-poor settings, leading to underestimation of true prevalence rates. Mass drug administration programs are unsustainable long-term, and diagnostic tools - required to be rapid, specific, sensitive, cost-effective, and user-friendly without specialized equipment and expertise - are urgently needed for rapid mapping of helminthic diseases and monitoring control programs. We describe the key features of the CRISPR-Cas12/13 system and emphasise its potential for the development of effective tools for the diagnosis of parasitic and other neglected tropical diseases (NTDs), a key recommendation of the NTDs 2021-2030 roadmap released by the World Health Organization.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Parasites / Parasitic Diseases / COVID-19 Type of study: Diagnostic study / Observational study Limits: Animals / Humans Language: English Journal: Bioessays Journal subject: Biology / Molecular Biology Year: 2022 Document Type: Article Affiliation country: Bies.202100286

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Parasites / Parasitic Diseases / COVID-19 Type of study: Diagnostic study / Observational study Limits: Animals / Humans Language: English Journal: Bioessays Journal subject: Biology / Molecular Biology Year: 2022 Document Type: Article Affiliation country: Bies.202100286