Potential of the CRISPR-Cas system for improved parasite diagnosis: CRISPR-Cas mediated diagnosis in parasitic infections: CRISPR-Cas mediated diagnosis in parasitic infections.
Bioessays
; 44(4): e2100286, 2022 04.
Article
in English
| MEDLINE | ID: covidwho-1680275
ABSTRACT
CRISPR-Cas technology accelerates development of fast, accurate, and portable diagnostic tools, typified by recent applications in COVID-19 diagnosis. Parasitic helminths cause devastating diseases afflicting 1.5 billion people globally, representing a significant public health and economic burden, especially in developing countries. Currently available diagnostic tests for worm infection are neither sufficiently sensitive nor field-friendly for use in low-endemic or resource-poor settings, leading to underestimation of true prevalence rates. Mass drug administration programs are unsustainable long-term, and diagnostic tools - required to be rapid, specific, sensitive, cost-effective, and user-friendly without specialized equipment and expertise - are urgently needed for rapid mapping of helminthic diseases and monitoring control programs. We describe the key features of the CRISPR-Cas12/13 system and emphasise its potential for the development of effective tools for the diagnosis of parasitic and other neglected tropical diseases (NTDs), a key recommendation of the NTDs 2021-2030 roadmap released by the World Health Organization.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Parasites
/
Parasitic Diseases
/
COVID-19
Type of study:
Diagnostic study
/
Observational study
Limits:
Animals
/
Humans
Language:
English
Journal:
Bioessays
Journal subject:
Biology
/
Molecular Biology
Year:
2022
Document Type:
Article
Affiliation country:
Bies.202100286
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