A case report: Clozapine-induced leukopenia and neutropenia after mRNA COVID-19 vaccination.
Neuropsychopharmacol Rep
; 42(2): 238-240, 2022 06.
Article
in English
| MEDLINE | ID: covidwho-1680520
ABSTRACT
Clozapine is an atypical antipsychotic used for treatment-resistant schizophrenia and is known to cause serious side effects, such as leukopenia and neutropenia. We encountered the case of a 44-year-old female patient with a good response to clozapine, who experienced inflammatory reaction and cytopenia after coronavirus disease 2019 (COVID-19) vaccination. Soon after clozapine discontinuation, the inflammatory reaction resolved, and cell counts recovered. There are only a few reports on the interaction between clozapine and COVID-19 vaccine. Our findings suggest that caution is required when a patient who is receiving clozapine scheduled for COVID-19 vaccination, owing to the possibility of cytopenia. Moreover, blood tests and the measurement of clozapine concentration should be performed before and after the inoculation to ensure patient safety.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Schizophrenia
/
Clozapine
/
COVID-19
/
COVID-19 Drug Treatment
/
Neutropenia
Type of study:
Case report
/
Experimental Studies
/
Observational study
Topics:
Vaccines
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Neuropsychopharmacol Rep
Year:
2022
Document Type:
Article
Affiliation country:
Npr2.12238
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