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Role of diabetes mellitus in the clinical course and outcome of SARS-CoV-2 infected patients.
Maltezou, Helena C; Pavli, Androula; Tsonou, Paraskevi; Balaska, Asimina; Raftopoulos, Vasilios; Papadima, Kalliopi; Andreopoulou, Anastasia; Tentolouris, Anastasios; Gamaletsou, Maria N; Sipsas, Nikolaos V; Tentolouris, Nikolaos.
  • Maltezou HC; Directorate of Research, Studies and Documentation, National Public Health Organization, Athens, Greece. maltezou.helena@gmail.com.
  • Pavli A; Department of Travel Medicine, National Public Health Organization, Athens, Greece.
  • Tsonou P; Department of Travel Medicine, National Public Health Organization, Athens, Greece.
  • Balaska A; Directorate of Non-Communicable Diseases, National Public Health Organization, Athens, Greece.
  • Raftopoulos V; HIV Surveillance Division, National Public Health Organization, Athens, Greece.
  • Papadima K; Department of Respiratory Infections, Directorate of Epidemiological Surveillance and Interventions for Infectious Diseases, National Public Health Organization, Athens, Greece.
  • Andreopoulou A; Department of Respiratory Infections, Directorate of Epidemiological Surveillance and Interventions for Infectious Diseases, National Public Health Organization, Athens, Greece.
  • Tentolouris A; First Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Gamaletsou MN; Pathophysiology Department, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Sipsas NV; Pathophysiology Department, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Tentolouris N; First Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Hormones (Athens) ; 21(2): 221-227, 2022 Jun.
Article in English | MEDLINE | ID: covidwho-1682540
ABSTRACT

PURPOSE:

Our aim was to study patients with diabetes mellitus and SARS-CoV-2-infection diagnosed during the first pandemic wave in Greece.

METHODS:

Cases were retrieved from the national database of SARS-CoV-2 infections.

RESULTS:

We studied 2624 SARS-CoV-2 infected cases, including 157 with diabetes. Patients with diabetes more often had other comorbidities (68.8 vs. 24.1%; p-value < 0.001). Among patients with diabetes, 149 (94.9%) developed symptomatic disease (COVID-19) compared to 1817 patients (73.7%) without diabetes (p-value < 0.001). A total of 126 patients with diabetes and COVID-19 were hospitalized and 41 died (27.5% case-fatality rate compared to 7.5% among patients without diabetes; p-value < 0.001). Patients with diabetes more often were hospitalized, developed complications, were admitted to the intensive care unit (ICU), received invasive mechanical ventilation, and died compared to patients without diabetes (p-values < 0.001 to 0.002 for all comparisons). Multivariate logistic regression analyses revealed that diabetes, having other comorbidities, and older age were significantly associated with higher risk for hospitalization, ICU admission, invasive mechanical ventilation, and death, and that obesity was significantly associated with higher risk for hospitalization, ICU admission, and mechanical intubation, while female gender protected against these outcomes.

CONCLUSION:

COVID-19 is associated with increased rates of serious morbidity and adverse outcome in patients with diabetes and represents a severe illness for them.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus / COVID-19 Type of study: Observational study / Prognostic study Limits: Female / Humans Language: English Journal: Hormones (Athens) Journal subject: Endocrinology Year: 2022 Document Type: Article Affiliation country: S42000-021-00342-x

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus / COVID-19 Type of study: Observational study / Prognostic study Limits: Female / Humans Language: English Journal: Hormones (Athens) Journal subject: Endocrinology Year: 2022 Document Type: Article Affiliation country: S42000-021-00342-x