Treatment of valproic acid overdose with meropenem in an epileptic patient.
Am J Emerg Med
; 53: 284.e1-284.e3, 2022 Mar.
Article
in English
| MEDLINE | ID: covidwho-1682857
ABSTRACT
Valproic acid (VPA) and derivatives are effective anticonvulsants that are also used for numerous mood disorders. VPA toxicity can cause central nervous system (CNS) depression, dose related hyperammonemia, and eventually hepatotoxicity. While traditional treatment of VPA toxicity often includes l-carnitine, activated charcoal, and hemodialysis; an interaction with carbapenem class antibiotics has been well established in literature and may offer a different avenue of treatment. This case describes a 38 year-old female with a past medical history of epilepsy effectively treated with meropenem to rapidly and safely lower toxic VPA levels after an acute ingestion. A review of four VPA poisoning case reports and the interaction with carbapenem class antibiotics is also included.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Epilepsy
/
Drug Overdose
Type of study:
Case report
/
Prognostic study
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Am J Emerg Med
Year:
2022
Document Type:
Article
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