Virome characterization of game animals in China reveals a spectrum of emerging pathogens.
Cell
; 185(7): 1117-1129.e8, 2022 03 31.
Article
in English
| MEDLINE | ID: covidwho-1682965
ABSTRACT
Game animals are wildlife species traded and consumed as food and are potential reservoirs for SARS-CoV and SARS-CoV-2. We performed a meta-transcriptomic analysis of 1,941 game animals, representing 18 species and five mammalian orders, sampled across China. From this, we identified 102 mammalian-infecting viruses, with 65 described for the first time. Twenty-one viruses were considered as potentially high risk to humans and domestic animals. Civets (Paguma larvata) carried the highest number of potentially high-risk viruses. We inferred the transmission of bat-associated coronavirus from bats to civets, as well as cross-species jumps of coronaviruses from bats to hedgehogs, from birds to porcupines, and from dogs to raccoon dogs. Of note, we identified avian Influenza A virus H9N2 in civets and Asian badgers, with the latter displaying respiratory symptoms, as well as cases of likely human-to-wildlife virus transmission. These data highlight the importance of game animals as potential drivers of disease emergence.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Disease Reservoirs
/
Communicable Diseases, Emerging
/
Virome
/
Animals, Wild
/
Mammals
Type of study:
Prognostic study
/
Randomized controlled trials
/
Reviews
Limits:
Animals
Country/Region as subject:
Asia
Language:
English
Journal:
Cell
Year:
2022
Document Type:
Article
Affiliation country:
J.cell.2022.02.014
Similar
MEDLINE
...
LILACS
LIS