The impact of physical conditions on the incidence of major depressive disorder in Chinese university students: Results from a longitudinal study.
J Affect Disord
; 303: 301-305, 2022 04 15.
Article
in English
| MEDLINE | ID: covidwho-1683226
ABSTRACT
BACKGROUND:
Major depressive disorder (MDD) is prevalent, and highly comorbid with physical illnesses. Few longitudinal studies have investigated the relationship between physical health conditions and MDD. The objectives of this study were to investigate the comorbid relationship between physical conditions and MDD, and the association between physical conditions and the 2-year risk of MDD.METHODS:
A study was conducted in first-year Chinese university students (n = 8,079) over two and half years, using a longitudinal design. An adapted version of the Composite International Diagnostic Interview (CIDI - 3.0) was used to assess for MDD. The presence of physician diagnosed physical conditions was assessed using ten self-report questions. Cross-sectional and longitudinal associations between self-reported physical conditions and MDD were estimated, adjusting for possible confounders.RESULTS:
The most frequently reported physical conditions were migraines, chronic rhinitis, and gastritis. We found that migraines, gastritis, and stomach ulcers were associated with a significantly higher lifetime prevalence of MDD than those without any physical health conditions. In those without a lifetime MDD, migraines, gastritis and stomach ulcers were also found to be significant predictors for 2-year risk of new onset MDD.LIMITATIONS:
Recall and selection biases are possible when using self-reporting measures. Additionally, the COVID-19 outbreak impacted the response rate at the second follow-up assessment. Lastly, the severity of the physical conditions was not measured.CONCLUSIONS:
Physical conditions and MDD are highly prevalent and comorbid in university students. Migraines, gastritis and stomach ulcers are associated with the risk of developing MDD. Future studies should further investigate how this information can be used to prevent MDD.Keywords
Acronyms: MDD = major depressive disorder; BAI = beck anxiety inventory; CIDI = composite international diagnostic interview; CI = confidence interval; Major depressive disorder; OR = odds ratio; PHQ-9 = patient health questionnaire-9; Physical conditions; T0 = baseline; T1 = first follow up; T2 = second follow up; University students; comorbidity; n = sample size
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Depressive Disorder, Major
/
COVID-19
Type of study:
Cohort study
/
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
J Affect Disord
Year:
2022
Document Type:
Article
Affiliation country:
J.jad.2022.02.041
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