Relationships between the Fear of COVID-19 Scale and regional brain atrophy in mild cognitive impairment.
Acta Neuropsychiatr
; 34(3): 153-162, 2022 Jun.
Article
in English
| MEDLINE | ID: covidwho-1683863
ABSTRACT
BACKGROUND:
Several studies have reported that the pandemic of coronavirus disease 2019 (COVID-19) influenced cognitive function in the elderly. However, the effect of COVID-19-related fear on brain atrophy has not been evaluated. In this study, we evaluated the relation between brain atrophy and the effect of COVID-19-related fear by analysing changes in brain volume over time using magnetic resonance imaging (MRI).METHODS:
Participants were 25 Japanese patients with mild cognitive impairment (MCI) or subjective cognitive decline (SCD), who underwent 1.5-tesla MRI scan twice, once before and once after the pandemic outbreak of COVID-19, and the Fear of Coronavirus Disease 2019 Scale (FCV-19S) assessment during that period. We computed regional brain atrophy per day between the 1st and 2nd scan, and evaluated the relation between the FCV-19S scores and regional shrinkage.RESULTS:
There was significant positive correlation between the total FCV-19S score and volume reduction per day in the right posterior cingulate cortex. Regarding the subscales of FCV-19S, we found significant positive correlation between factor 2 of the FCV-19S and shrinkage of the right posterior cingulate cortex.CONCLUSIONS:
There was positive correlation between the FCV-19S score and regional brain atrophy per day. Although it is already known that the psychological effects surrounding the COVID-19 pandemic cause cognitive function decline, our results further suggest that anxiety and fear related to COVID-19 cause regional brain atrophy.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Cognitive Dysfunction
/
COVID-19
Type of study:
Experimental Studies
/
Prognostic study
/
Qualitative research
Topics:
Long Covid
Limits:
Aged
/
Humans
Language:
English
Journal:
Acta Neuropsychiatr
Year:
2022
Document Type:
Article
Affiliation country:
Neu.2022.7
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