Progress Identifying and Analyzing the Human Proteome: 2021 Metrics from the HUPO Human Proteome Project.
J Proteome Res
; 20(12): 5227-5240, 2021 12 03.
Article
in English
| MEDLINE | ID: covidwho-1683909
ABSTRACT
The 2021 Metrics of the HUPO Human Proteome Project (HPP) show that protein expression has now been credibly detected (neXtProt PE1 level) for 18â¯357 (92.8%) of the 19â¯778 predicted proteins coded in the human genome, a gain of 483 since 2020 from reports throughout the world reanalyzed by the HPP. Conversely, the number of neXtProt PE2, PE3, and PE4 missing proteins has been reduced by 478 to 1421. This represents remarkable progress on the proteome parts list. The utilization of proteomics in a broad array of biological and clinical studies likewise continues to expand with many important findings and effective integration with other omics platforms. We present highlights from the Immunopeptidomics, Glycoproteomics, Infectious Disease, Cardiovascular, Musculo-Skeletal, Liver, and Cancers B/D-HPP teams and from the Knowledgebase, Mass Spectrometry, Antibody Profiling, and Pathology resource pillars, as well as ethical considerations important to the clinical utilization of proteomics and protein biomarkers.
Keywords
Biology and Disease-HPP (B/D-HPP); Chromosome-centric HPP (C-HPP); Human Protein Atlas; Human Proteome Project (HPP); Mass Spectrometry Interactive Virtual Environment (MassIVE); PeptideAtlas; missing proteins (MP); neXtProt protein existence (PE) metrics; non-MS PE1 proteins; uncharacterized protein existence 1 (uPE1)
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Benchmarking
/
Proteome
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
J Proteome Res
Journal subject:
Biochemistry
Year:
2021
Document Type:
Article
Affiliation country:
Acs.jproteome.1c00590
Similar
MEDLINE
...
LILACS
LIS