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BNT162b2 Messenger RNA Vaccination Did Not Prevent an Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 Variant 501Y.V2 in an Elderly Nursing Home but Reduced Transmission and Disease Severity.
Bailly, Benoit; Guilpain, Luc; Bouiller, Kevin; Chirouze, Catherine; N'Debi, Melissa; Soulier, Alexandre; Demontant, Vanessa; Pawlotsky, Jean-Michel; Rodriguez, Christophe; Fourati, Slim.
  • Bailly B; Department of Infectious Disease, University Hospital of Besançon, Besançon, France.
  • Guilpain L; Department of Infectious Disease, Hospital of Lons Le Saunier, Lons Le Saunier, France.
  • Bouiller K; Department of Medical Laboratory, Hospital of Lons Le Saunier, Lons Le Saunier, France.
  • Chirouze C; Department of Infectious Disease, Hospital of Lons Le Saunier, Lons Le Saunier, France.
  • N'Debi M; UMR-CNRS 6249 Chrono-environnement, Université Bourgogne Franche-Comté, Besançon, France.
  • Soulier A; Department of Infectious Disease, Hospital of Lons Le Saunier, Lons Le Saunier, France.
  • Demontant V; UMR-CNRS 6249 Chrono-environnement, Université Bourgogne Franche-Comté, Besançon, France.
  • Pawlotsky JM; Genomics Platform, Hôpital Henri Mondor (AP-HP), Université Paris-Est, Créteil, France.
  • Rodriguez C; Virology Unit, Department of Prevention, Diagnosis and Treatment of Infections, Hôpital Henri Mondor (AP-HP), Université Paris-Est, Créteil, France.
  • Fourati S; Genomics Platform, Hôpital Henri Mondor (AP-HP), Université Paris-Est, Créteil, France.
Clin Infect Dis ; 74(3): 517-520, 2022 02 11.
Article in English | MEDLINE | ID: covidwho-1684545
ABSTRACT
We report an outbreak of severe acute respiratory syndrome coronavirus 2 501Y.V2 in a nursing home. All nonvaccinated residents (5/5) versus half of those vaccinated with BNT162b2 (13/26) were infected. Two of 13 vaccinated versus 4 of 5 nonvaccinated residents presented severe disease. BNT162b2 did not prevent the outbreak, but reduced transmission and disease severity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Vaccines / Variants Limits: Aged / Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Vaccines / Variants Limits: Aged / Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid