Activation of circulating platelets in vaccine-induced thrombotic thrombocytopenia and its reversal by intravenous immunoglobulin.

McFadyen, James D; Sharma, Prerna; Moon, Mitchell J; Noonan, Jonathan; Goodall, Elizabeth; Tran, Huyen A; Peter, Karlheinz

McFadyen, James D; Sharma, Prerna; Moon, Mitchell J; Noonan, Jonathan; Goodall, Elizabeth; Tran, Huyen A; Peter, Karlheinz.

McFadyen JD; Atherothrombosis and Vascular Biology, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Sharma P; Department of Clinical Hematology, The Alfred Hospital, Melbourne, Victoria, Australia.
Moon MJ; Department of Medicine, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
Noonan J; Baker Department of Cardiometabolic Health, University of Melbourne, Melbourne, Victoria, Australia.
Goodall E; Atherothrombosis and Vascular Biology, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Tran HA; Atherothrombosis and Vascular Biology, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Peter K; Baker Department of Cardiometabolic Health, University of Melbourne, Melbourne, Victoria, Australia.

Br J Haematol ; 196(1): 234-237, 2022 01.

Article in English | MEDLINE | ID: covidwho-1685223

Subject(s)

Blood Platelets/immunology; Blood Platelets/metabolism; Immunoglobulins, Intravenous; Thrombocytopenia/etiology; Thrombocytopenia/therapy; Vaccines/adverse effects; Biomarkers; COVID-19 Vaccines/adverse effects; Disease Management; Disease Susceptibility; Female; Humans; Immunoglobulins, Intravenous/therapeutic use; Immunophenotyping; Middle Aged; Platelet Count; Thrombocytopenia/blood; Thrombocytopenia/diagnosis; Treatment Outcome

Keywords

immunotherapy; platelet activation; platelet aggregation; vaccines

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombocytopenia / Blood Platelets / Vaccines / Immunoglobulins, Intravenous Type of study: Case report / Diagnostic study / Prognostic study Topics: Vaccines Limits: Female / Humans / Middle aged Language: English Journal: Br J Haematol Year: 2022 Document Type: Article Affiliation country: Bjh.17750

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