Newly developed type 1 diabetes after coronavirus disease 2019 vaccination: A case report.
J Diabetes Investig
; 13(6): 1105-1108, 2022 Jun.
Article
in English
| MEDLINE | ID: covidwho-1685351
ABSTRACT
The vaccine for the coronavirus disease 2019 (COVID-19) has been reported to potentially cause or worsen diabetes. A 73-year-old Japanese woman received two doses of Moderna COVID-19 vaccine. Four weeks after the second vaccination, her glycemic control began to deteriorate, and 8 weeks after the second vaccination, the patient was diagnosed with new-onset type 1 diabetes that was strongly positive for autoantibodies and showed a disease-susceptible human leukocyte antigen haplotype, DRB1*040501-DQB1*040101. The glucagon stimulation test suggested an insulin-dependent state, and induction of intensive insulin therapy brought about fair glycemic control. The time period from the COVID-19 vaccination to the development of type 1 diabetes was relatively longer than to the onset or exacerbation of type 2 diabetes, as previously reported, suggesting the complicated immunological mechanisms for the destruction of ß-cells associated with the vaccination. In recipients with the disease-susceptible haplotypes, one should be cautious about autoimmune responses for several months after the vaccination.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Diabetes Mellitus, Type 1
/
Diabetes Mellitus, Type 2
/
COVID-19
Type of study:
Case report
/
Observational study
Topics:
Vaccines
Limits:
Aged
/
Female
/
Humans
Language:
English
Journal:
J Diabetes Investig
Year:
2022
Document Type:
Article
Affiliation country:
Jdi.13757
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