Your browser doesn't support javascript.
Late inflammatory reactions in patients with soft tissue fillers after SARS-CoV-2 infection and vaccination: A systematic review of the literature.
Bachour, Yara; Bekkenk, Marcel W; Rustemeyer, Thomas; Kadouch, Jonathan A.
  • Bachour Y; Public Health Service (GGD) Amsterdam, Amsterdam, The Netherlands.
  • Bekkenk MW; Department of Dermatology and Allergology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
  • Rustemeyer T; Department of Dermatology and Allergology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
  • Kadouch JA; Department of Dermatology, ReSculpt Clinic, Amsterdam, The Netherlands.
J Cosmet Dermatol ; 21(4): 1361-1368, 2022 Apr.
Article in English | MEDLINE | ID: covidwho-1685366
ABSTRACT

INTRODUCTION:

Soft tissue fillers are used for cosmetic and reconstructive purposes, and soft tissue filler procedures are among the most common nonsurgical procedures in the USA. Although soft tissue filler procedures are relatively quick and safe, adverse events such as late inflammatory reactions have been reported with every filler product. Infections and vaccinations have been proposed as potential triggers for late inflammatory reactions (LIRs), and it is therefore not surprising that these adverse events have been reported after SARS-CoV-2 infection and vaccination. Therefore, this review aims to give a detailed overview of these cases. MATERIALS AND

METHODS:

A literature search was undertaken on LIRs in patients with a history of soft tissue filler use after SARS-CoV-2 infection or vaccination. This systematic review was reported according to the PRISMA guidelines. We searched the electronic database PubMed from January 2020 to August 2021. Data on patient characteristics, filler characteristics, clinical findings, and treatment options were included.

RESULTS:

This review included 7 articles with a total of 19 patients with LIRs after SARS-CoV-2 infection or vaccination. Three patients with postinfection LIRs and 16 patients with postvaccination LIRs were reported. These LIRS mainly occurred in females who had HA injections for cosmetic purposes. Three patients with postinfection LIRs had symptoms of facial swelling and/or lip angioedema in a matter of weeks. Sixteen patients reported reactions after SARS-CoV-2 vaccination (13 following Moderna vaccination and 3 after Pfizer vaccination, after both the first and second doses) from 13 hours up to three weeks. These patients presented with similar clinical symptoms as patients with postinfection LIRs. All patients were treated in a conservative manner.

DISCUSSION:

This review shows a relationship between LIRs and SARS-CoV-2 infection and vaccination. In the case of vaccination, these adverse events have been reported only after Moderna and Pfizer vaccinations. The reported adverse events are generally minor and self-limiting, and we encourage patients with soft tissue fillers to participate in vaccination programs.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Long Covid / Vaccines Limits: Female / Humans Language: English Journal: J Cosmet Dermatol Journal subject: Dermatology Year: 2022 Document Type: Article Affiliation country: Jocd.14840

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Long Covid / Vaccines Limits: Female / Humans Language: English Journal: J Cosmet Dermatol Journal subject: Dermatology Year: 2022 Document Type: Article Affiliation country: Jocd.14840