Lethal mutagenesis as an antiviral strategy.

Swanstrom, Ronald; Schinazi, Raymond F

Swanstrom, Ronald; Schinazi, Raymond F.

Swanstrom R; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Schinazi RF; Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA, USA.

Science ; 375(6580): 497-498, 2022 Feb 04.

Article in English | MEDLINE | ID: covidwho-1685476

ABSTRACT

ABSTRACT

[Figure see text].

Subject(s)

Antiviral Agents/pharmacology; Cytidine/analogs & derivatives; Hydroxylamines/pharmacology; Mutagenesis; RNA Viruses/drug effects; SARS-CoV-2/drug effects; Animals; Antiviral Agents/adverse effects; Antiviral Agents/therapeutic use; COVID-19/virology; Cytidine/adverse effects; Cytidine/metabolism; Cytidine/pharmacology; Cytidine/therapeutic use; Cytidine/toxicity; DNA/biosynthesis; Evolution, Molecular; Genome, Viral; Humans; Hydroxylamines/adverse effects; Hydroxylamines/metabolism; Hydroxylamines/therapeutic use; Mutagenicity Tests; Phosphorylation; RNA Virus Infections/drug therapy; RNA Virus Infections/virology; RNA Viruses/genetics; RNA, Viral/biosynthesis; RNA, Viral/genetics; Ribonucleosides/metabolism; SARS-CoV-2/genetics; COVID-19 Drug Treatment

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / RNA Viruses / Mutagenesis / Cytidine / SARS-CoV-2 / Hydroxylamines Type of study: Diagnostic study Limits: Animals / Humans Language: English Journal: Science Year: 2022 Document Type: Article Affiliation country: Science.abn0048

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