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Intrahepatic cholestasis of pregnancy resistant to both therapeutic plasma exchange and albumin dialysis.
Lia, Massimiliano; Berg, Thomas; Weydandt, Laura Christina; Stepan, Holger.
  • Lia M; Department of Obstetrics, Leipzig University Hospital, Leipzig, Germany massimiliano.lia@medizin.uni-leipzig.de.
  • Berg T; Department of Hepatology, Leipzig University Hospital, Leipzig, Germany.
  • Weydandt LC; Department of Obstetrics, Leipzig University Hospital, Leipzig, Germany.
  • Stepan H; Department of Obstetrics, Leipzig University Hospital, Leipzig, Germany.
BMJ Case Rep ; 15(2)2022 Feb 08.
Article in English | MEDLINE | ID: covidwho-1685516
ABSTRACT
Intrahepatic cholestasis in pregnancy (ICP) represents, depending on its severity, a serious risk for the fetus. Those cases with unusually high bile acid levels may be resistant to pharmaceutical treatment and can be treated with plasma exchange or albumin dialysis. However, the success rate of these therapeutic options and the factors influencing therapeutic response are unknown. Furthermore, if these options fail to improve ICP and serum bile acid levels are very high (>200 µm/L), there are no clear recommendations when delivery should be planned. Here, we report a patient with severe ICP resistant to both therapeutic plasma exchange and albumin dialysis. Caesarean section was performed at 32 weeks of gestation followed by rapid remission of ICP.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications / Cholestasis, Intrahepatic Type of study: Case report / Prognostic study Limits: Female / Humans / Pregnancy Language: English Year: 2022 Document Type: Article Affiliation country: Bcr-2021-246318

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications / Cholestasis, Intrahepatic Type of study: Case report / Prognostic study Limits: Female / Humans / Pregnancy Language: English Year: 2022 Document Type: Article Affiliation country: Bcr-2021-246318