Predictive value of D-dimer in the clinical outcome of severe COVID19 patients: Are we giving it too much credit?
Clin Appl Thromb Hemost
; 28: 10760296221079612, 2022.
Article
in English
| MEDLINE | ID: covidwho-1685921
ABSTRACT
BACKGROUND:
COVID-19 is a new form of acute respiratory failure leading to multiorgan failure and ICU admission. Gathered evidence suggests that a 3-fold rise in D-dimer concentrations may be linked to poor prognosis and higher mortality.PURPOSE:
To describe D-dimer admission profile in severe ICU COVID19 patients and its predictive role in outcomes and mortality.METHODS:
Single-center retrospective cohort study. All adult patients admitted to ICU with COVID19 were divided into 3 groups (1) Lower-values group (D-dimer levels < 3-fold normal range value [NRV] [500ng/mL]), Intermediate-values group (D-dimer ≥3-fold and <10-fold NRV) and Higher-value group (≥10-fold NRV).RESULTS:
118 patients (mean age 63 years, 73% males) were included (N = 73 Lower-values group, N = 31 Intermediate-values group; N = 11 Higher-values group). Mortality was not different between groups (p = 0.51). Kaplan-Meier survival curves revealed no differences (p = 0.52) between groups, nor it was verified even when gender, age, ICU length of stay, and SOFA score were considered as covariables.CONCLUSIONS:
In severe COVID19 patients, the D-dimer profile does not retain a predictive value regarding patients' survivability and should not be used as a surrogate of disease severity.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Fibrin Fibrinogen Degradation Products
/
COVID-19
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Clin Appl Thromb Hemost
Journal subject:
Vascular Diseases
Year:
2022
Document Type:
Article
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