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Activation of Intracellular Complement in Lungs of Patients With Severe COVID-19 Disease Decreases T-Cell Activity in the Lungs.
Howell, Mark C; Green, Ryan; McGill, Andrew R; Kahlil, Roukiah M; Dutta, Rinku; Mohapatra, Shyam S; Mohapatra, Subhra.
  • Howell MC; Department of Internal Medicine, Morsani College of Medicine, University of South Florida (USF), Tampa, FL, United States.
  • Green R; James A. Haley Veterans Hospital, Department of Veterans Affairs, Tampa, FL, United States.
  • McGill AR; Department of Internal Medicine, Morsani College of Medicine, University of South Florida (USF), Tampa, FL, United States.
  • Kahlil RM; James A. Haley Veterans Hospital, Department of Veterans Affairs, Tampa, FL, United States.
  • Dutta R; Department of Internal Medicine, Morsani College of Medicine, University of South Florida (USF), Tampa, FL, United States.
  • Mohapatra SS; James A. Haley Veterans Hospital, Department of Veterans Affairs, Tampa, FL, United States.
  • Mohapatra S; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida (USF), Tampa, FL, United States.
Front Immunol ; 12: 700705, 2021.
Article in English | MEDLINE | ID: covidwho-1686468
ABSTRACT
A novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), arose late in 2019, with disease pathology ranging from asymptomatic to severe respiratory distress with multi-organ failure requiring mechanical ventilator support. It has been found that SARS-CoV-2 infection drives intracellular complement activation in lung cells that tracks with disease severity. However, the cellular and molecular mechanisms responsible remain unclear. To shed light on the potential mechanisms, we examined publicly available RNA-Sequencing data using CIBERSORTx and conducted a Ingenuity Pathway Analysis to address this knowledge gap. In complement to these findings, we used bioinformatics tools to analyze publicly available RNA sequencing data and found that upregulation of complement may be leading to a downregulation of T-cell activity in lungs of severe COVID-19 patients. Thus, targeting treatments aimed at the modulation of classical complement and T-cell activity may help alleviate the proinflammatory effects of COVID-19, reduce lung pathology, and increase the survival of COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Complement System Proteins / T-Lymphocytes / Complement Activation / Gene Expression Profiling / COVID-19 / Lung Type of study: Prognostic study Limits: Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.700705

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Complement System Proteins / T-Lymphocytes / Complement Activation / Gene Expression Profiling / COVID-19 / Lung Type of study: Prognostic study Limits: Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.700705