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Low Serum Levels of Interferon Alpha in COVID-19 Patients Are Associated with Older Age.
Alidjinou, Enagnon Kazali; Hirabidian, Mickael; Rabat, Anthony; Ouafi, Mahdi; Nekoua, Magloire Pandoua; Sane, Famara; Poissy, Julien; Hober, Didier.
  • Alidjinou EK; Laboratoire de Virologie ULR3610, University of Lille, CHU Lille, F-59000 Lille, France.
  • Hirabidian M; Laboratoire de Virologie ULR3610, University of Lille, CHU Lille, F-59000 Lille, France.
  • Rabat A; Laboratoire de Virologie ULR3610, University of Lille, CHU Lille, F-59000 Lille, France.
  • Ouafi M; Laboratoire de Virologie ULR3610, University of Lille, CHU Lille, F-59000 Lille, France.
  • Nekoua MP; Laboratoire de Virologie ULR3610, University of Lille, CHU Lille, F-59000 Lille, France.
  • Sane F; Laboratoire de Virologie ULR3610, University of Lille, CHU Lille, F-59000 Lille, France.
  • Poissy J; Pôle de Réanimation, CNRS, UMR 8576-UGSF, Inserm U1285, University of Lille, CHU Lille, F-59000 Lille, France.
  • Hober D; Laboratoire de Virologie ULR3610, University of Lille, CHU Lille, F-59000 Lille, France.
J Clin Med ; 11(4)2022 Feb 12.
Article in English | MEDLINE | ID: covidwho-1686845
ABSTRACT
Innate immune response, especially type 1 interferon (IFN) response is considered to play a substantial role in the outcome of SARS-CoV-2 infection. A reduced and delayed IFN response has been associated with progression to severe COVID-19. In this study, we investigated levels of circulating IFNα and serum neutralizing activity in COVID-19 patients admitted to the intensive care unit. We found a significant association of levels of IFNα with age (p = 0.007). This association has also been observed in a cohort of COVID-19 outpatients with mild infection (p = 0.02). The impact of senescence on IFN response can explain the higher susceptibility of the elderly to severe COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Jcm11040961

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Jcm11040961