Your browser doesn't support javascript.
microRNAs and Inflammatory Immune Response in SARS-CoV-2 Infection: A Narrative Review.
Maranini, Beatrice; Ciancio, Giovanni; Ferracin, Manuela; Cultrera, Rosario; Negrini, Massimo; Sabbioni, Silvia; Govoni, Marcello.
  • Maranini B; Rheumatology Unit, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.
  • Ciancio G; Rheumatology Unit, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.
  • Ferracin M; Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, 40138 Bologna, Italy.
  • Cultrera R; Infectious Diseases, Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
  • Negrini M; Laboratorio per le Tecnologie delle Terapie Avanzate (LTTA), Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
  • Sabbioni S; Department of Life Sciences and Biotechnologies, University of Ferrara, 44121 Ferrara, Italy.
  • Govoni M; Rheumatology Unit, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.
Life (Basel) ; 12(2)2022 Feb 15.
Article in English | MEDLINE | ID: covidwho-1686871
ABSTRACT
The current SARS-CoV-2 pandemic has emerged as an international challenge with strong medical and socioeconomic impact. The spectrum of clinical manifestations of SARS-CoV-2 is wide, covering asymptomatic or mild cases up to severe and life-threatening complications. Critical courses of SARS-CoV-2 infection are thought to be driven by the so-called "cytokine storm", derived from an excessive immune response that induces the release of proinflammatory cytokines and chemokines. In recent years, non-coding RNAs (ncRNAs) emerged as potential diagnostic and therapeutic biomarkers in both inflammatory and infectious diseases. Therefore, the identification of SARS-CoV-2 miRNAs and host miRNAs is an important research topic, investigating the host-virus crosstalk in COVID-19 infection, trying to answer the pressing question of whether miRNA-based therapeutics can be employed to tackle SARS-CoV-2 complications. In this review, we aimed to directly address ncRNA role in SARS-CoV-2-immune system crosstalk upon COVID-19 infection, particularly focusing on inflammatory pathways and cytokine storm syndromes.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Reviews Language: English Year: 2022 Document Type: Article Affiliation country: Life12020288

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Reviews Language: English Year: 2022 Document Type: Article Affiliation country: Life12020288