Your browser doesn't support javascript.
A Perspective on the Roles of Adjuvants in Developing Highly Potent COVID-19 Vaccines.
Zhang, Naru; Li, Kangchen; Liu, Zezhong; Nandakumar, Kutty Selva; Jiang, Shibo.
  • Zhang N; Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, China.
  • Li K; Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou 310015, China.
  • Liu Z; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China.
  • Nandakumar KS; Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17177 Stockholm, Sweden.
  • Jiang S; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China.
Viruses ; 14(2)2022 02 14.
Article in English | MEDLINE | ID: covidwho-1687054
ABSTRACT
Several countries have made unremitting efforts to develop an optimal vaccine in the fight against coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With the increasing occurrence of SARS-CoV-2 variants, current vaccines show decreased neutralizing activities, especially towards the Omicron variant. In this context, adding appropriate adjuvants to COVID-19 vaccines can substantially reduce the number of required doses and improve efficacy or cross-neutralizing protection. We mainly focus on research progress and achievements associated with adjuvanted COVID-19 subunit and inactivated vaccines. We further compare the advantages and disadvantages of different adjuvant formulations in order to provide a scientific reference for designing an effective strategy for future vaccine development.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Adjuvants, Immunologic / COVID-19 Vaccines / SARS-CoV-2 Type of study: Randomized controlled trials Topics: Vaccines / Variants Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: V14020387

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Adjuvants, Immunologic / COVID-19 Vaccines / SARS-CoV-2 Type of study: Randomized controlled trials Topics: Vaccines / Variants Limits: Humans Language: English Year: 2022 Document Type: Article Affiliation country: V14020387