Literature Review of Hemadsorption Therapy in Severe COVID-19 Cases: a Narrative Review.
Clin Lab
; 68(2)2022 Feb 01.
Article
in English
| MEDLINE | ID: covidwho-1687428
ABSTRACT
BACKGROUND:
A novel therapy for reducing the cytokines in the circulatory system used for severe COVID-19 cases was hemoperfusion or hemadsorption method. Although the hemoperfusion methods have been shown to be beneficial in the cytokine storm during influenza infection, it is not known to what extent it is successful for COVID-19 patients. Therefore, the purpose of this study is to review the studies on severe COVID-19 treated with the hemoperfusion methods.METHODS:
A literature search was conducted using the databases PubMed, Science Direct, and Springer databases. Since the included articles consisted of case reports, case series, and one controlled trial, only the mean of the analyzed data could be calculated.RESULTS:
Sixteen studies were included in the narrative review, including 86 patients with severe COVID-19. All the patients had hemoperfusion therapy with following cartridges CytoSorb®, oXiris®, Biosky filter, SeaStar® CLR filter, HA280, HA330 Jafron©, and resin directed hemadsorption cartridges. Mortality rate, the mean of intubation time, duration in intensive care unit and hospital were 29%, 14.93 days, 17.21 days, and 31.7 days, respectively. The mean values of C-reactive protein and interleukin-6 decreased after hemoperfusion sessions (131.7 to 66.0, 527.5 to 334.7, respectively).CONCLUSIONS:
In this narrative review, it is demonstrated that hemadsorption therapy is an alternative salvage treatment method in critically ill COVID-19 patients, but the data must be supported by strong evidence.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Hemoperfusion
/
COVID-19
Type of study:
Experimental Studies
/
Randomized controlled trials
/
Reviews
Limits:
Humans
Language:
English
Journal subject:
Laboratory Techniques and procedures
Year:
2022
Document Type:
Article
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