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Risk factors for post-COVID-19 condition in previously hospitalised children using the ISARIC Global follow-up protocol: a prospective cohort study.
Osmanov, Ismail M; Spiridonova, Ekaterina; Bobkova, Polina; Gamirova, Aysylu; Shikhaleva, Anastasia; Andreeva, Margarita; Blyuss, Oleg; El-Taravi, Yasmin; DunnGalvin, Audrey; Comberiati, Pasquale; Peroni, Diego G; Apfelbacher, Christian; Genuneit, Jon; Mazankova, Lyudmila; Miroshina, Alexandra; Chistyakova, Evgeniya; Samitova, Elmira; Borzakova, Svetlana; Bondarenko, Elena; Korsunskiy, Anatoliy A; Konova, Irina; Hanson, Sarah Wulf; Carson, Gail; Sigfrid, Louise; Scott, Janet T; Greenhawt, Matthew; Whittaker, Elizabeth A; Garralda, Elena; Swann, Olivia V; Buonsenso, Danilo; Nicholls, Dasha E; Simpson, Frances; Jones, Christina; Semple, Malcolm G; Warner, John O; Vos, Theo; Olliaro, Piero; Munblit, Daniel.
  • Osmanov IM; Z.A. Bashlyaeva Children's Municipal Clinical Hospital, Moscow, Russia.
  • Spiridonova E; Pirogov Russian National Research Medical University, Moscow, Russia.
  • Bobkova P; These authors contributed equally to this article.
  • Gamirova A; Dept of Paediatrics and Paediatric Infectious Diseases, Institute of Child's Health, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
  • Shikhaleva A; These authors contributed equally to this article.
  • Andreeva M; Dept of Paediatrics and Paediatric Infectious Diseases, Institute of Child's Health, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
  • Blyuss O; These authors contributed equally to this article.
  • El-Taravi Y; Dept of Paediatrics and Paediatric Infectious Diseases, Institute of Child's Health, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
  • DunnGalvin A; These authors contributed equally to this article.
  • Comberiati P; Dept of Paediatrics and Paediatric Infectious Diseases, Institute of Child's Health, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
  • Peroni DG; These authors contributed equally to this article.
  • Apfelbacher C; Dept of Paediatrics and Paediatric Infectious Diseases, Institute of Child's Health, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
  • Genuneit J; These authors contributed equally to this article.
  • Mazankova L; Dept of Paediatrics and Paediatric Infectious Diseases, Institute of Child's Health, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
  • Miroshina A; School of Physics, Astronomy and Mathematics, University of Hertfordshire, Hatfield, UK.
  • Chistyakova E; These authors contributed equally to this article.
  • Samitova E; Dept of Paediatrics and Paediatric Infectious Diseases, Institute of Child's Health, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
  • Borzakova S; Dept of Paediatrics and Paediatric Infectious Diseases, Institute of Child's Health, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
  • Bondarenko E; School of Applied Psychology, University College Cork, Cork City, Ireland.
  • Korsunskiy AA; Dept of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, Italy.
  • Konova I; Dept of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, Italy.
  • Hanson SW; Institute of Social Medicine and Health Systems Research, Faculty of Medicine, Otto von Guericke University Magdeburg, Magdeburg, Germany.
  • Carson G; Pediatric Epidemiology, Dept of Pediatrics, Medical Faculty, Leipzig University, Leipzig, Germany.
  • Sigfrid L; Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation, Moscow, Russia.
  • Scott JT; Z.A. Bashlyaeva Children's Municipal Clinical Hospital, Moscow, Russia.
  • Greenhawt M; Dept of Paediatrics and Paediatric Rheumatology, Institute of Child's Health, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
  • Whittaker EA; Z.A. Bashlyaeva Children's Municipal Clinical Hospital, Moscow, Russia.
  • Garralda E; Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation, Moscow, Russia.
  • Swann OV; Pirogov Russian National Research Medical University, Moscow, Russia.
  • Buonsenso D; Research Institute for Healthcare Organization and Medical Management of Moscow Healthcare Dept, Moscow, Russia.
  • Nicholls DE; Dept of Paediatrics and Paediatric Infectious Diseases, Institute of Child's Health, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
  • Simpson F; Dept of Paediatrics and Paediatric Infectious Diseases, Institute of Child's Health, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
  • Jones C; Z.A. Bashlyaeva Children's Municipal Clinical Hospital, Moscow, Russia.
  • Semple MG; Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.
  • Warner JO; ISARIC Global Support Centre, Nuffield Dept of Medicine, University of Oxford, Oxford, UK.
  • Vos T; ISARIC Global Support Centre, Nuffield Dept of Medicine, University of Oxford, Oxford, UK.
  • Olliaro P; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
  • Munblit D; Dept of Pediatrics, Section of Allergy/Immunology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA.
Eur Respir J ; 59(2)2022 Feb.
Article in English | MEDLINE | ID: covidwho-1690989
ABSTRACT

BACKGROUND:

The long-term sequelae of coronavirus disease 2019 (COVID-19) in children remain poorly characterised. This study aimed to assess long-term outcomes in children previously hospitalised with COVID-19 and associated risk factors.

METHODS:

This is a prospective cohort study of children (≤18 years old) admitted to hospital with confirmed COVID-19. Children admitted between 2 April 2020 and 26 August 2020 were included. Telephone interviews used the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) COVID-19 Health and Wellbeing Follow-up Survey for Children. Persistent symptoms (>5 months) were further categorised by system(s) involved.

RESULTS:

518 out of 853 (61%) eligible children were available for the follow-up assessment and included in the study. Median (interquartile range (IQR)) age was 10.4 (3-15.2) years and 270 (52.1%) were girls. Median (IQR) follow-up since hospital discharge was 256 (223-271) days. At the time of the follow-up interview 126 (24.3%) participants reported persistent symptoms, among which fatigue (53, 10.7%), sleep disturbance (36, 6.9%) and sensory problems (29, 5.6%) were the most common. Multiple symptoms were experienced by 44 (8.4%) participants. Risk factors for persistent symptoms were older age "6-11 years" (OR 2.74, 95% CI 1.37-5.75) and "12-18 years" (OR 2.68, 95% CI 1.41-5.4), and a history of allergic diseases (OR 1.67, 95% CI 1.04-2.67).

CONCLUSIONS:

A quarter of children experienced persistent symptoms months after hospitalisation with acute COVID-19 infection, with almost one in 10 experiencing multisystem involvement. Older age and allergic diseases were associated with higher risk of persistent symptoms at follow-up.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Aged / Child / Female / Humans Language: English Year: 2022 Document Type: Article Affiliation country: 13993003.01341-2021

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Adolescent / Aged / Child / Female / Humans Language: English Year: 2022 Document Type: Article Affiliation country: 13993003.01341-2021