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A SARS-CoV-2 ferritin nanoparticle vaccine elicits protective immune responses in nonhuman primates.
Joyce, M Gordon; King, Hannah A D; Elakhal-Naouar, Ines; Ahmed, Aslaa; Peachman, Kristina K; Macedo Cincotta, Camila; Subra, Caroline; Chen, Rita E; Thomas, Paul V; Chen, Wei-Hung; Sankhala, Rajeshwer S; Hajduczki, Agnes; Martinez, Elizabeth J; Peterson, Caroline E; Chang, William C; Choe, Misook; Smith, Clayton; Lee, Parker J; Headley, Jarrett A; Taddese, Mekdi G; Elyard, Hanne A; Cook, Anthony; Anderson, Alexander; McGuckin Wuertz, Kathryn; Dong, Ming; Swafford, Isabella; Case, James Brett; Currier, Jeffrey R; Lal, Kerri G; Molnar, Sebastian; Nair, Manoj S; Dussupt, Vincent; Daye, Sharon P; Zeng, Xiankun; Barkei, Erica K; Staples, Hilary M; Alfson, Kendra; Carrion, Ricardo; Krebs, Shelly J; Paquin-Proulx, Dominic; Karasavva, Nicos; Polonis, Victoria R; Jagodzinski, Linda L; Amare, Mihret F; Vasan, Sandhya; Scott, Paul T; Huang, Yaoxing; Ho, David D; de Val, Natalia; Diamond, Michael S.
  • Joyce MG; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
  • King HAD; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Elakhal-Naouar I; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
  • Ahmed A; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Peachman KK; U.S. Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
  • Macedo Cincotta C; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Subra C; Diagnostics and Countermeasures Branch, WRAIR, Silver Spring, MD 20910, USA.
  • Chen RE; Viral Diseases Branch, WRAIR, Silver Spring, MD 20910, USA.
  • Thomas PV; Diagnostics and Countermeasures Branch, WRAIR, Silver Spring, MD 20910, USA.
  • Chen WH; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Sankhala RS; Diagnostics and Countermeasures Branch, WRAIR, Silver Spring, MD 20910, USA.
  • Hajduczki A; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
  • Martinez EJ; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Peterson CE; U.S. Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
  • Chang WC; Department of Medicine, Washington University, St. Louis, MO 63130, USA.
  • Choe M; Department of Pathology and Immunology, Washington University, St. Louis, MO 63130, USA.
  • Smith C; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
  • Lee PJ; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Headley JA; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
  • Taddese MG; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Elyard HA; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
  • Cook A; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Anderson A; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
  • McGuckin Wuertz K; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Dong M; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
  • Swafford I; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Case JB; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
  • Currier JR; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Lal KG; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
  • Molnar S; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Nair MS; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
  • Dussupt V; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Daye SP; Center for Molecular Microscopy, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
  • Zeng X; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
  • Barkei EK; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Staples HM; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
  • Alfson K; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Carrion R; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
  • Krebs SJ; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Paquin-Proulx D; Bioqual, Rockville, MD 20850, USA.
  • Karasavva N; Bioqual, Rockville, MD 20850, USA.
  • Polonis VR; U.S. Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
  • Jagodzinski LL; Oak Ridge Institute of Science and Education, Oak Ridge, TN 37830, USA.
  • Amare MF; U.S. Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
  • Vasan S; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
  • Scott PT; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Huang Y; U.S. Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
  • Ho DD; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research (WRAIR), Silver Spring, MD 20910, USA.
  • de Val N; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD 20817, USA.
  • Diamond MS; U.S. Military HIV Research Program, WRAIR, Silver Spring, MD 20910, USA.
Sci Transl Med ; 14(632): eabi5735, 2022 Feb 16.
Article in English | MEDLINE | ID: covidwho-1691438
ABSTRACT
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants stresses the continued need for next-generation vaccines that confer broad protection against coronavirus disease 2019 (COVID-19). We developed and evaluated an adjuvanted SARS-CoV-2 spike ferritin nanoparticle (SpFN) vaccine in nonhuman primates. High-dose (50 µg) SpFN vaccine, given twice 28 days apart, induced a Th1-biased CD4 T cell helper response and elicited neutralizing antibodies against SARS-CoV-2 wild-type and variants of concern, as well as against SARS-CoV-1. These potent humoral and cell-mediated immune responses translated into rapid elimination of replicating virus in the upper and lower airways and lung parenchyma of nonhuman primates following high-dose SARS-CoV-2 respiratory challenge. The immune response elicited by SpFN vaccination and resulting efficacy in nonhuman primates supports the utility of SpFN as a vaccine candidate for SARS-causing betacoronaviruses.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Nanoparticles / COVID-19 Type of study: Experimental Studies Topics: Vaccines / Variants Limits: Animals / Humans Language: English Journal: Sci Transl Med Journal subject: Science / Medicine Year: 2022 Document Type: Article Affiliation country: Scitranslmed.abi5735

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Nanoparticles / COVID-19 Type of study: Experimental Studies Topics: Vaccines / Variants Limits: Animals / Humans Language: English Journal: Sci Transl Med Journal subject: Science / Medicine Year: 2022 Document Type: Article Affiliation country: Scitranslmed.abi5735