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Association study between herpes zoster reporting and mRNA COVID-19 vaccines (BNT162b2 and mRNA-1273).
Préta, Laure-Hélène; Contejean, Adrien; Salvo, Francesco; Treluyer, Jean-Marc; Charlier, Caroline; Chouchana, Laurent.
  • Préta LH; Département de Pharmacologie, Centre Régional de Pharmacovigilance, Hôpital Cochin, Paris, France.
  • Contejean A; Equipe mobile d'infectiologie, Hôpital Cochin, Paris, France.
  • Salvo F; Université Paris Descartes, Paris, France.
  • Treluyer JM; Inserm, Bordeaux Population Health Research Center, Team Pharmacoepidemiology, Univ. Bordeaux, Bordeaux, France.
  • Charlier C; CHU de Bordeaux, Service de Pharmacologie Médicale, Centre Régional de Pharmacovigilance de Bordeaux, Bordeaux, France.
  • Chouchana L; Département de Pharmacologie, Centre Régional de Pharmacovigilance, Hôpital Cochin, Paris, France.
Br J Clin Pharmacol ; 88(7): 3529-3534, 2022 07.
Article in English | MEDLINE | ID: covidwho-1691620
ABSTRACT
Several cases of herpes zoster (HZ) following mRNA COVID-19 vaccination (BNT162b2 and mRNA-1273) have been reported, and the first epidemiological evidence suggests an increased risk. We used the worldwide pharmacovigilance database VigiBase to describe HZ cases following mRNA COVID-19 vaccination. We performed disproportionality analyses (case/non-case statistical approach) to assess the relative risk of HZ reporting in mRNA COVID-19 vaccine recipients compared to influenza vaccine recipients and according to patient age. To 30 June 2021, of 716 928 reports with mRNA COVID-19 vaccines, we found 7728 HZ cases. When compared to influenza vaccines, mRNA COVID-19 vaccines were associated with a significantly higher reporting of HZ (reporting odds ratio 1.9, 95% CI 1.8-2.1). Furthermore, we found a reduced risk of reporting HZ among under 40-year-old persons compared to older persons (reporting odds ratio 0.39, 95% CI 0.36-0.41). Mild and infrequent HZ reactions may occur shortly after mRNA COVID-19 vaccination, at higher frequency than reported with influenza vaccination, especially in patients over 40 years old. Further analyses are needed to confirm this risk.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / Herpes Zoster Vaccine / COVID-19 / Herpes Zoster Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Adult / Aged / Humans Language: English Journal: Br J Clin Pharmacol Year: 2022 Document Type: Article Affiliation country: Bcp.15280

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / Herpes Zoster Vaccine / COVID-19 / Herpes Zoster Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Adult / Aged / Humans Language: English Journal: Br J Clin Pharmacol Year: 2022 Document Type: Article Affiliation country: Bcp.15280