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B cells in systemic lupus erythematosus.
Szelinski, Franziska; Lino, Andreia C; Dörner, Thomas.
  • Szelinski F; Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin.
  • Lino AC; Freie Universität Berlin, Humboldt-Universität zu Berlin, the Berlin Institute of Health.
  • Dörner T; German Rheumatism Research Center Berlin (DRFZ), a Leibniz Institute, Berlin, Germany.
Curr Opin Rheumatol ; 34(2): 125-132, 2022 03 01.
Article in English | MEDLINE | ID: covidwho-2319704
ABSTRACT
PURPOSE OF REVIEW New insight into altered B cell distribution including newly identified subsets and abnormalities in systemic lupus erythematosus (SLE) as well as their role in immune protection are summarized in this review. RECENT

FINDINGS:

SLE carries characteristic B cell abnormalities, which offer new insights into B cell differentiation and their disturbances including discoveries of pathogenic B cell subsets and intrinsic B cell abnormalities. A recent study in SLE found that antigen-experienced B cell subsets lacking expression of CD27 and IgD defined by their lack of CXCR5 and CD19low expression are expanded in SLE and represent plasmablasts likely escaping proper selection. In terms of therapeutic targeting with broader coverage than rituximab, second-generation anti-CD20, anti-CD38 and CD19-CART treatment experiences have advanced our understanding recently. However, the key role of qualitative and quantitative B cell requirements in connection with T cells became apparent during SARS-Cov2 infection and vaccination, especially in patients with gradual B cell impairments by rituximab, mycophenolate mofetil and cyclophosphamide.

SUMMARY:

Identification and characterization relevant B cell subsets together with altered regulatory mechanisms in SLE facilitates new approaches in targeting pathogenic B cells but require consideration of preservation of protection.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Lupus Erythematosus, Systemic Type of study: Qualitative research Topics: Vaccines Limits: Humans Language: English Journal: Curr Opin Rheumatol Journal subject: Rheumatology Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Lupus Erythematosus, Systemic Type of study: Qualitative research Topics: Vaccines Limits: Humans Language: English Journal: Curr Opin Rheumatol Journal subject: Rheumatology Year: 2022 Document Type: Article