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Significant Reduction in Vaccine-Induced Antibody Levels and Neutralization Activity Among Healthcare Workers and Nursing Home Residents 6 Months Following Coronavirus Disease 2019 BNT162b2 mRNA Vaccination.
Canaday, David H; Oyebanji, Oladayo A; Keresztesy, Debbie; Payne, Michael; Wilk, Dennis; Carias, Lenore; Aung, Htin; St Denis, Kerri; Lam, Evan C; Rowley, Christopher F; Berry, Sarah D; Cameron, Cheryl M; Cameron, Mark J; Wilson, Brigid M; Balazs, Alejandro B; King, Christopher L; Gravenstein, Stefan.
  • Canaday DH; Division of Infectious Disease, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • Oyebanji OA; Geriatric Research, Education and Clinical Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
  • Keresztesy D; Division of Infectious Disease, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • Payne M; Division of Infectious Disease, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • Wilk D; Division of Infectious Disease, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • Carias L; Division of Infectious Disease, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • Aung H; Division of Infectious Disease, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • St Denis K; Division of Infectious Disease, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • Lam EC; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA.
  • Rowley CF; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA.
  • Berry SD; Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
  • Cameron CM; Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA.
  • Cameron MJ; Division of Infectious Disease, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • Wilson BM; Division of Infectious Disease, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
  • Balazs AB; Geriatric Research, Education and Clinical Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
  • King CL; Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA.
  • Gravenstein S; Division of Infectious Disease, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Clin Infect Dis ; 2021 Nov 19.
Article in English | MEDLINE | ID: covidwho-1692242
ABSTRACT
Antibody decline occurred from 2 weeks to 6 months post-BNT162b2 mRNA vaccination in nursing home (NH) residents and healthcare workers. Antispike, receptor-binding domain, and neutralization levels dropped >81% irrespective of prior infection. Notably, 69% of infection-naive NH residents had neutralizing antibodies at or below the assay's limit of detection.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid

Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal subject: Communicable Diseases Year: 2021 Document Type: Article Affiliation country: Cid