Disparities by Sex in COVID-19 Risk and Related Harms Among People with Opioid Use Disorder.
J Womens Health (Larchmt)
; 31(5): 640-647, 2022 05.
Article
in English
| MEDLINE | ID: covidwho-1692279
ABSTRACT
Objectives:
(1) Report sex-specific prevalence of coronavirus disease 2019 (COVID-19) test positivity among an opioid use disorder (OUD) cohort (2) Assess sex-specific rates of opioid overdose and mortality.Methods:
A retrospective cohort study was performed on all adult patients with OUD who received a COVID-19 test in calendar year 2020 at a large academic medical center in Richmond, Virginia. Our study outcomes were positive COVID-19 test, opioid overdose, and all-cause in-hospital mortality. Sex-stratified multivariable logistic regression assessed sociodemographic factors associated with COVID-19 test positivity.Results:
A total of 2,600 patients (males = 1,294, females = 1,306) with OUD received a COVID-19 test. Approximately 5% across both sexes tested positive for COVID-19 (p = 0.420), whereas 7% presented with an opioid overdose (males 10%; females 4%; p < 0.0001). However, mortality rates were similar across sex. Among males, individuals in the other racial group had increased odds of COVID-19 test positivity (adjusted odds ratio or AOR 5.03, 95% confidence interval [CI] 1.70-14.88), whereas black females had higher odds of COVID-19 test positivity (AOR 1.92, 95% CI 1.01-3.62) compared to their white counterparts.Conclusions:
Opioid overdose, more often than COVID-19, impacted the health of patients with OUD presenting to a public safety net health system. Despite a female advantage documented in the general population for COVID-19 susceptibility, COVID-19 test positivity rates were similar across sex in an OUD cohort; yet, racial disparities emerged with notable sex-related variation. Sex and gender are important variables that modify health outcomes, including OUD and COVID-19, and should be further investigated using an intersectionality framework.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Opiate Overdose
/
COVID-19
/
Opioid-Related Disorders
Type of study:
Cohort study
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
J Womens Health (Larchmt)
Journal subject:
Gynecology
/
Women's Health
Year:
2022
Document Type:
Article
Affiliation country:
JWH.2021.0457
Similar
MEDLINE
...
LILACS
LIS