Interleukin-1 Receptor-Like 2: One Receptor, Three Agonists, and Many Implications.
J Interferon Cytokine Res
; 42(2): 49-61, 2022 02.
Article
in English
| MEDLINE | ID: covidwho-1692282
ABSTRACT
The interleukin (IL)-1 superfamily of cytokines comprises 11 pro- and anti-inflammatory cytokines, which play essential roles during the immune response. Several pathogenic pathways are initiated by IL-1RL2 (interleukin 1 receptor-like 2) signaling, also known as IL-36R, in the skin, lungs, and gut. IL-36 cytokines promote the secretion of proinflammatory cytokines and chemokines, upregulation of antimicrobial peptides, proliferation mediators, and adhesion molecules on endothelial cells. In addition, the IL-36-IL-1RL2 axis has an essential role against viral infections, including a potential role in COVID-19 pathology. The evidence presented in this review highlights the importance of the axis IL-36-IL-1RL2 in the development of several inflammation-related diseases and the healing process. It suggests that IL-1RL2 ligands have specific roles depending on the tissue or cell source. However, there is still much to discover about this cytokine family, their functions in other organs, and how they accomplish a dual effect in inflammation and healing.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Receptors, Interleukin-1
/
Inflammation
Limits:
Animals
/
Humans
Language:
English
Journal:
J Interferon Cytokine Res
Journal subject:
Allergy and Immunology
Year:
2022
Document Type:
Article
Affiliation country:
Jir.2021.0173
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