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The interplay of viral loads, clinical presentation, and serological responses in SARS-CoV-2 - Results from a prospective cohort of outpatient COVID-19 cases.
Puchinger, Kerstin; Castelletti, Noemi; Rubio-Acero, Raquel; Geldmacher, Christof; Eser, Tabea M; Deák, Flora; Paunovic, Ivana; Bakuli, Abhishek; Saathoff, Elmar; von Meyer, Alexander; Markgraf, Alisa; Falk, Philine; Reich, Jakob; Riess, Friedrich; Girl, Philipp; Müller, Katharina; Radon, Katja; Guggenbuehl Noller, Jessica Michelle; Wölfel, Roman; Hoelscher, Michael; Kroidl, Inge; Wieser, Andreas; Olbrich, Laura.
  • Puchinger K; Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany.
  • Castelletti N; Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany; Institute of Radiation Medicine, Helmholtz Zentrum München, 85764, Neuherberg, Germany. Electronic address: castelletti@lrz.uni-muenchen.de.
  • Rubio-Acero R; Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany.
  • Geldmacher C; Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Germany.
  • Eser TM; Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Germany.
  • Deák F; Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Germany.
  • Paunovic I; Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany.
  • Bakuli A; Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany.
  • Saathoff E; Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Germany.
  • von Meyer A; Institute for Laboratory Medicine, Medical Microbiology and Technical Hygienics, Munich Municipal Hospital Group, 81675, Munich, Germany.
  • Markgraf A; Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany.
  • Falk P; Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany.
  • Reich J; Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany.
  • Riess F; Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Germany.
  • Girl P; German Center for Infection Research (DZIF), Partner Site Munich, Germany; Bundeswehr Institute of Microbiology, 80937, Munich, Germany.
  • Müller K; German Center for Infection Research (DZIF), Partner Site Munich, Germany; Bundeswehr Institute of Microbiology, 80937, Munich, Germany.
  • Radon K; Center for International Health, Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital Munich (LMU), Ziemssenstr. 1, 80336, Munich, Germany.
  • Guggenbuehl Noller JM; Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany.
  • Wölfel R; German Center for Infection Research (DZIF), Partner Site Munich, Germany; Bundeswehr Institute of Microbiology, 80937, Munich, Germany.
  • Hoelscher M; Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Germany.
  • Kroidl I; Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Germany.
  • Wieser A; Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Germany.
  • Olbrich L; Division of Infectious Diseases and Tropical Medicine, University Hospital, LMU Munich, 80802, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, Germany; Oxford Vaccine Group, Department of Paediatrics, And the NIHR Oxford Biomedical Research Centre, University of Ox
Virology ; 569: 37-43, 2022 04.
Article in English | MEDLINE | ID: covidwho-1692814
ABSTRACT
Risk factors for disease progression and severity of SARS-CoV-2 infections require an understanding of acute and long-term virological and immunological dynamics. Fifty-one RT-PCR positive COVID-19 outpatients were recruited between May and December 2020 in Munich, Germany, and followed up at multiple defined timepoints for up to one year. RT-PCR and viral culture were performed and seroresponses measured. Participants were classified applying the WHO clinical progression scale. Short symptom to test time (median 5.0 days; p = 0.0016) and high viral loads (VL; median maximum VL 3∙108 copies/mL; p = 0.0015) were indicative for viral culture positivity. Participants with WHO grade 3 at baseline had significantly higher VLs compared to those with WHO 1 and 2 (p = 0.01). VLs dropped fast within 1 week of symptom onset. Maximum VLs were positively correlated with the magnitude of Ro-N-Ig seroresponse (p = 0.022). Our results describe the dynamics of VLs and antibodies to SARS-CoV-2 in mild to moderate cases that can support public health measures during the ongoing global pandemic.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Load / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Etiology study / Incidence study / Observational study / Risk factors Topics: Long Covid Limits: Adolescent / Adult / Child / Humans / Middle aged / Young adult Language: English Journal: Virology Year: 2022 Document Type: Article Affiliation country: J.virol.2022.02.002

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Load / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Etiology study / Incidence study / Observational study / Risk factors Topics: Long Covid Limits: Adolescent / Adult / Child / Humans / Middle aged / Young adult Language: English Journal: Virology Year: 2022 Document Type: Article Affiliation country: J.virol.2022.02.002