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Clinical characteristics and outcome of coronavirus disease 2019 infection in patients with solid organ transplants: A systematic review and meta-analysis.
An, Wen; Wang, Qiuyang; Kim, Tae-Eun; Kang, Ju-Seop.
  • An W; Department of Pharmacology & Clinical Pharmacology, College of Medicine, Hanyang University, Seoul, South Korea. Electronic address: anwen@hanyang.ac.kr.
  • Wang Q; Department of Central China Research Institute of Health, Xinxiang Medical University, Xinxiang, China. Electronic address: 202034@xxmu.edu.cn.
  • Kim TE; Department of Clinical Pharmacology, Konkuk University Hospital, Seoul, South Korea. Electronic address: tekim@kuh.ac.kr.
  • Kang JS; Department of Pharmacology & Clinical Pharmacology, College of Medicine, Hanyang University, Seoul, South Korea. Electronic address: jskang@hanyang.ac.kr.
J Infect Public Health ; 15(3): 365-372, 2022 Mar.
Article in English | MEDLINE | ID: covidwho-1693249
ABSTRACT

BACKGROUND:

Although many studies have reported cases of COVID-19 infection in transplant recipients, most of them only involve a small number of patients and narrow geographic areas. This study aims to investigate the clinical characteristics, morbidity, severity, and mortality of COVID-19 infection among solid organ transplant (SOT) recipients by meta-analysis.

METHOD:

We performed a literature search using the databases PubMed, Web of Science, and Google Scholar as of November 26, 2020. We included randomized controlled trials and cohort studies, excluding case reports and small case series (n < 10). The pooled incidence proportion and 95% confidence intervals (CI) were used to estimate the combined results of forty-seven studies were included for the meta-analysis. Heterogeneity was assessed using I2. Freeman-Tukey double arcsine transformation was used to stabilize the specific rate variance. Publication bias was using Egger's test.

RESULTS:

The morbidity rate of COVID-19 in SOT recipients was 2.10% [95% CI 1.35-3.01], and the proportion of severe infection was 22.46% [95% CI 15.74-29.90]. The mortality rate was 17.38% [95% CI 13.72-21.34]. In the analysis by transplanted organ, the proportion of patients with severe infection was highest in recipients of two or more transplants 48.85% [95% CI 11.88-86.38]. The mortality rate was highest in lung transplant recipients 25.12% [95% CI 16.94-34.00]. The most common symptoms of COVID-19 in SOT recipients were fever (73.39%), cough (58.90%), and respiratory symptoms (45.77%).

CONCLUSION:

SOT was a risk factor for worse COVID-19 outcomes, although the morbidity of COVID-19 in SOT recipients was not markedly higher than the general population. These results may change when our understanding of the disease progress.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Organ Transplantation / Transplant Recipients / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Humans Language: English Journal: J Infect Public Health Journal subject: Communicable Diseases / Public Health Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Organ Transplantation / Transplant Recipients / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Humans Language: English Journal: J Infect Public Health Journal subject: Communicable Diseases / Public Health Year: 2022 Document Type: Article