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Taiwan's Response to Influenza: A Seroepidemiological Evaluation of Policies and Implications for Pandemic Preparedness.
Ho, Pui-I; Liu, Wei; Li, Tiger Zheng-Rong; Chan, Ta-Chien; Ku, Chia-Chi; Lien, Yu-Hui; Shen, Yea-Huei Daphne; Chen, Juine-Ruey; Yen, Muh-Yong; Tu, Yu-Kang; Lin, Wan-Yu; Compans, Richard; Lee, Ping-Ing; King, Chwan-Chuen.
  • Ho PI; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University (NTU), Taipei, Taiwan.
  • Liu W; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University (NTU), Taipei, Taiwan.
  • Li TZ; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University (NTU), Taipei, Taiwan.
  • Chan TC; Research Center for Humanities & Social Sciences, Academia Sinica, Taipei, Taiwan.
  • Ku CC; Institute of Immunology, College of Medicine, NTU, Taipei, Taiwan.
  • Lien YH; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University (NTU), Taipei, Taiwan.
  • Shen YD; Department of Infection, Yuan's General Hospital, Kaohsiung City, Taiwan; StatPlus, Inc., Taipei, Taiwan.
  • Chen JR; RuenHuei Biopharmaceuticals, Inc., Taipei, Taiwan.
  • Yen MY; Taipei City Hospital, Taipei, Taiwan.
  • Tu YK; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University (NTU), Taipei, Taiwan.
  • Lin WY; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University (NTU), Taipei, Taiwan.
  • Compans R; Department of Microbiology and Immunology and Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America (U.S.A.).
  • Lee PI; Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address: pinging@ntu.edu.tw.
  • King CC; Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University (NTU), Taipei, Taiwan. Electronic address: chwanchuen@gmail.com.
Int J Infect Dis ; 121: 226-237, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-1697884
ABSTRACT

OBJECTIVES:

To evaluate class suspension and mass vaccination implemented among Taipei schoolchildren during the 2009 influenza pandemic and investigate factors affecting antibody responses.

METHODS:

We conducted 2 cohort studies on (1) 972 schoolchildren from November 2009-March 2010 to evaluate pandemic policies and (2) 935 schoolchildren from November 2011-March 2012 to verify factors in antibody waning. Anti-influenza H1N1pdm09 hemagglutination inhibition antibodies (HI-Ab) were measured from serum samples collected before vaccination, and at 1 and 4 months after vaccination. Factors affecting HI-Ab responses were investigated through logistic regression and generalized estimating equation.

RESULTS:

Seroprevalence of H1N1pdm09 before vaccination was significantly higher among schoolchildren who experienced class suspensions than those who did not (59.6% vs 47.5%, p<0.05). Participating in after-school activities (adjusted odds ratio [aOR]=2.47, p=0.047) and having ≥3 hours per week of exercise (aOR=2.86, p=0.019) were significantly correlated with H1N1pdm09 infection. Two doses of the H1N1pdm09 vaccine demonstrated significantly better antibody persistence than 1 dose (HI-Ab geometric mean titer 132.5 vs 88.6, p=0.047). Vaccine effectiveness after controlling for preexisting immunity was 86% (32%-97%). Exercise ≥3 hours per week and preexisting immunity were significantly associated with antibody waning/maintenance.

CONCLUSIONS:

This study is the first to show that exercise and preexisting immunity may affect antibody waning. Further investigation is needed to identify immune correlates of protection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / Influenza, Human / Influenza A Virus, H1N1 Subtype Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Child / Humans Country/Region as subject: Asia Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: J.ijid.2022.02.038

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / Influenza, Human / Influenza A Virus, H1N1 Subtype Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Child / Humans Country/Region as subject: Asia Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: J.ijid.2022.02.038