Reversible thiol oxidation of the MAVS signaling adaptor: a novel regulatory mechanism of the antiviral response

ABSTRACT

The development of an antiviral response against RNA viruses, including influenza, Respiratory Syncytial Virus or SARS-CoV-2, relies on the activation of MAVS, a mitochondrial and peroxisomal signaling hub protein. MAVS coordinates multiple signaling cascades that ultimately result in the production of interferons and proinflammatory cytokines essential to restrict virus replication and spreading.