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Genome Recombination between the Delta and Alpha Variants of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Sekizuka, Tsuyoshi; Itokawa, Kentaro; Saito, Masumichi; Shimatani, Michitsugu; Matsuyama, Shutoku; Hasegawa, Hideki; Saito, Tomoya; Kuroda, Makoto.
  • Sekizuka T; Pathogen Genomics Center, National Institute of Infectious Diseases, Japan.
  • Itokawa K; Pathogen Genomics Center, National Institute of Infectious Diseases, Japan.
  • Saito M; Center for Emergency Preparedness and Response, National Institute of Infectious Diseases, Japan.
  • Shimatani M; Center for Research Planning and Coordination, National Institute of Infectious Diseases, Japan.
  • Matsuyama S; Center for Influenza and Respiratory Virus Research, National Institute of Infectious Diseases, Murayama Branch, Japan.
  • Hasegawa H; Center for Influenza and Respiratory Virus Research, National Institute of Infectious Diseases, Murayama Branch, Japan.
  • Saito T; Center for Emergency Preparedness and Response, National Institute of Infectious Diseases, Japan.
  • Kuroda M; Pathogen Genomics Center, National Institute of Infectious Diseases, Japan.
Jpn J Infect Dis ; 75(4): 415-418, 2022 Jul 22.
Article in English | MEDLINE | ID: covidwho-1957587
ABSTRACT
Prominent genomic recombination has been observed between the Delta and Alpha variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), isolated from clinical specimens in Japan. Interestingly, the recombination variant detected in this study carries a spike protein identical to that in the domestic Delta variant, thereby suggesting that further risks would not be associated with infectivity and immune escape. The recombinant was classified as an XC lineage in the PANGOLIN database. It is necessary to intensively study such marked genetic variations and characterize emerging variants after careful verification of their lineage and clade assignment.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Variants Limits: Humans Country/Region as subject: Asia Language: English Journal: Jpn J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Yoken.jjid.2021.844

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Variants Limits: Humans Country/Region as subject: Asia Language: English Journal: Jpn J Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Yoken.jjid.2021.844