The major genetic risk factor for severe COVID-19 is associated with protection against HIV.
Proc Natl Acad Sci U S A
; 119(9)2022 03 01.
Article
in English
| MEDLINE | ID: covidwho-1699265
ABSTRACT
There are genetic risk factors that influence the outcome of COVID-19 [COVID-19 Host Genetics Initiative, Nature 600, 472-477 (2021)]. The major genetic risk factor for severe COIVD-19 resides on chromosome 3 and is inherited from Neandertals [H. Zeberg, S. Pääbo, Nature 587, 610-612 (2020)]. The risk-associated DNA segment modulates the expression of several chemokine receptors, among them CCR5, a coreceptor for HIV which is down-regulated in carriers of the COVID-19 risk haplotype. Here I show that carriers of the risk variant have an â¼27% lower risk of HIV infection.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Chromosomes, Human, Pair 3
/
Haplotypes
/
HIV Infections
/
HIV-1
/
SARS-CoV-2
/
COVID-19
Type of study:
Prognostic study
Topics:
Variants
Limits:
Humans
Language:
English
Year:
2022
Document Type:
Article
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