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Deaths related to pulmonary embolism and cardiovascular events before and during the 2020 COVID-19 pandemic: An epidemiological analysis of data from an Italian high-risk area.
Voci, Davide; Fedeli, Ugo; Farmakis, Ioannis T; Hobohm, Lukas; Keller, Karsten; Valerio, Luca; Schievano, Elena; Barbiellini Amidei, Claudio; Konstantinides, Stavros V; Kucher, Nils; Barco, Stefano.
  • Voci D; Department of Angiology, University Hospital Zurich, Zurich, Switzerland.
  • Fedeli U; Epidemiological Department, Azienda Zero, Veneto Region, Padua, Italy.
  • Farmakis IT; Center for Thrombosis and Hemostasis, Johannes Gutenberg University Mainz, Mainz, Germany.
  • Hobohm L; Center for Thrombosis and Hemostasis, Johannes Gutenberg University Mainz, Mainz, Germany; Department of Cardiology, Cardiology I, Johannes Gutenberg University Mainz, Mainz, Germany.
  • Keller K; Center for Thrombosis and Hemostasis, Johannes Gutenberg University Mainz, Mainz, Germany; Department of Cardiology, Cardiology I, Johannes Gutenberg University Mainz, Mainz, Germany.
  • Valerio L; Center for Thrombosis and Hemostasis, Johannes Gutenberg University Mainz, Mainz, Germany.
  • Schievano E; Epidemiological Department, Azienda Zero, Veneto Region, Padua, Italy.
  • Barbiellini Amidei C; Department of Cardiologic, Vascular and Thoracic Sciences and Public Health, University of Padova, Padova, Italy.
  • Konstantinides SV; Center for Thrombosis and Hemostasis, Johannes Gutenberg University Mainz, Mainz, Germany; Department of Cardiology, Democritus University of Thrace, Greece.
  • Kucher N; Department of Angiology, University Hospital Zurich, Zurich, Switzerland.
  • Barco S; Department of Angiology, University Hospital Zurich, Zurich, Switzerland; Center for Thrombosis and Hemostasis, Johannes Gutenberg University Mainz, Mainz, Germany. Electronic address: stefano.barco@usz.ch.
Thromb Res ; 212: 44-50, 2022 04.
Article in English | MEDLINE | ID: covidwho-1699972
ABSTRACT

BACKGROUND:

Pulmonary embolism is a known complication of coronavirus disease 2019 (COVID-19). Epidemiological population data focusing on pulmonary embolism-related mortality is limited.

METHODS:

Veneto is a region in Northern Italy counting 4,879,133 inhabitants in 2020. All ICD-10 codes from death certificates (1st January 2018 to 31st December 2020) were examined. Comparisons were made between 2020 (COVID-19 outbreak) and the average of the two-year period 2018-2019. All-cause, COVID-19-related and the following cardiovascular deaths have been studied pulmonary embolism, hypertensive disease, ischemic heart disease, atrial fibrillation/flutter, and cerebrovascular diseases.

RESULTS:

In 2020, a total of 56,412 deaths were recorded, corresponding to a 16% (n = 7806) increase compared to the period 2018-2019. The relative percentage increase during the so-called first and second waves was 19% and 44%, respectively. Of 7806 excess deaths, COVID-19 codes were reported in 90% of death certificates. The percentage increase in pulmonary embolism-related deaths was 27% (95%CI 19-35%), 1018 deaths during the year 2020, compared to 804 mean annual deaths in the period 2018-2019. This was more evident among men, who experience an absolute increase of 147 deaths (+45%), than in women (+67 deaths; +14%). The increase was primarily driven by deaths recorded during the second wave (+91% in October-December). An excess of deaths, particularly among men and during the second wave, was also observed for other cardiovascular diseases, notably hypertensive disease, atrial fibrillation, cerebrovascular disease, and ischemic heart disease.

CONCLUSIONS:

We observed a considerable increase of all-cause mortality during the year 2020. This was mainly driven by COVID-19 and its complications. The relative increase in the number of pulmonary embolism-related deaths was more prominent during the second wave, suggesting a possible underdiagnosis during the first wave.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Embolism / COVID-19 Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans / Male Country/Region as subject: Europa Language: English Journal: Thromb Res Year: 2022 Document Type: Article Affiliation country: J.THROMRES.2022.02.008

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Embolism / COVID-19 Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans / Male Country/Region as subject: Europa Language: English Journal: Thromb Res Year: 2022 Document Type: Article Affiliation country: J.THROMRES.2022.02.008