Your browser doesn't support javascript.
Severe Acute Respiratory Syndrome Coronavirus 2 Cumulative Incidence, United States, August 2020-December 2020.
Sullivan, Patrick Sean; Siegler, Aaron J; Shioda, Kayoko; Hall, Eric W; Bradley, Heather; Sanchez, Travis; Luisi, Nicole; Valentine-Graves, Mariah; Nelson, Kristin N; Fahimi, Mansour; Kamali, Amanda; Sailey, Charles; Lopman, Benjamin A.
  • Sullivan PS; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
  • Siegler AJ; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
  • Shioda K; Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
  • Hall EW; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
  • Bradley H; Department of Population Health Sciences, Georgia State University School of Public Health, Atlanta, Georgia, USA.
  • Sanchez T; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
  • Luisi N; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
  • Valentine-Graves M; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
  • Nelson KN; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
  • Fahimi M; Marketing Systems Group, Horsham, Pennsylvania, USA.
  • Kamali A; California Department of Public Health, Sacramento, California, USA.
  • Sailey C; Molecular Testing Labs, Vancouver, Washington, USA.
  • Lopman BA; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
Clin Infect Dis ; 74(7): 1141-1150, 2022 04 09.
Article in English | MEDLINE | ID: covidwho-1700667
ABSTRACT

BACKGROUND:

Reported coronavirus disease 2019 (COVID-19) cases underestimate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. We conducted a national probability survey of US households to estimate cumulative incidence adjusted for antibody waning.

METHODS:

From August-December 2020 a random sample of US addresses were mailed a survey and self-collected nasal swabs and dried blood spot cards. One adult household member completed the survey and mail specimens for viral detection and total (immunoglobulin [Ig] A, IgM, IgG) nucleocapsid antibody by a commercial, emergency use authorization-approved antigen capture assay. We estimated cumulative incidence of SARS-CoV-2 adjusted for waning antibodies and calculated reported fraction (RF) and infection fatality ratio (IFR). Differences in seropositivity among demographic, geographic, and clinical subgroups were explored.

RESULTS:

Among 39 500 sampled households, 4654 respondents provided responses. Cumulative incidence adjusted for waning was 11.9% (95% credible interval [CrI], 10.5%-13.5%) as of 30 October 2020. We estimated 30 332 842 (CrI, 26 703 753-34 335 338) total infections in the US adult population by 30 October 2020. RF was 22.3% and IFR was 0.85% among adults. Black non-Hispanics (Prevalence ratio (PR) 2.2) and Hispanics (PR, 3.1) were more likely than White non-Hispanics to be seropositive.

CONCLUSIONS:

One in 8 US adults had been infected with SARS-CoV-2 by October 2020; however, few had been accounted for in public health reporting. The COVID-19 pandemic is likely substantially underestimated by reported cases. Disparities in COVID-19 by race observed among reported cases cannot be attributed to differential diagnosis or reporting of infections in population subgroups.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Humans Country/Region as subject: North America Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Humans Country/Region as subject: North America Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid