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Sudan Black B treatment uncovers the distribution of angiotensin-converting enzyme2 in nociceptors.
Su, Si; Yu, Ning; Zhang, Hao; Wu, Danning; Cui, Huan; Ma, Chao.
  • Su S; Department of Anatomy, Histology and Embryology, Institute of Basic Medical Sciences, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine, 196536Peking Union Medical College, Beijing, China.
  • Yu N; Department of Anatomy, Histology and Embryology, Institute of Basic Medical Sciences, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine, 196536Peking Union Medical College, Beijing, China.
  • Zhang H; Department of Anatomy, Histology and Embryology, Institute of Basic Medical Sciences, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine, 196536Peking Union Medical College, Beijing, China.
  • Wu D; Department of Anatomy, Histology and Embryology, Institute of Basic Medical Sciences, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine, 196536Peking Union Medical College, Beijing, China.
  • Cui H; Department of Anatomy, Histology and Embryology, Institute of Basic Medical Sciences, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine, 196536Peking Union Medical College, Beijing, China.
  • Ma C; Department of Anatomy, Histology and Embryology, Institute of Basic Medical Sciences, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine, 196536Peking Union Medical College, Beijing, China.
Mol Pain ; 18: 17448069221080305, 2022.
Article in English | MEDLINE | ID: covidwho-1700706
ABSTRACT
Nervous system manifestations caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of great concern. Neurological symptoms and the neurological effects induced by SARS-CoV-2, such as the loss of various sensory perceptions, indicate direct viral invasion into sensory neurons. Therefore, it is very important to identify the distribution of angiotensin-converting enzyme 2 (ACE2), the receptor of SARS-CoV-2, in human nervous system. However, autofluorescence from lipofuscin obviously impacted immunofluorescence analysis in previous studies. We demonstrated that Sudan Black B (SBB) remarkably reduced the massive lipofuscin-like autofluorescence and the immunofluorescence signal would be sharpened following the exposure compensation. Additionally, we confirmed that ACE2 was expressed in IB4+, CGRP+, and NF200+ sensory subpopulations. The mapping of ACE2 distribution in hDRG would facilitate the understanding of sensory disorder induced by SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Peptidyl-Dipeptidase A / COVID-19 Limits: Humans Language: English Journal: Mol Pain Journal subject: Molecular Biology / Neurology / Psychophysiology Year: 2022 Document Type: Article Affiliation country: 17448069221080305

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Peptidyl-Dipeptidase A / COVID-19 Limits: Humans Language: English Journal: Mol Pain Journal subject: Molecular Biology / Neurology / Psychophysiology Year: 2022 Document Type: Article Affiliation country: 17448069221080305