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Contact-Tracing Outcomes Among Household Contacts of Fully Vaccinated Coronavirus Disease 2019 (COVID-19) Patients: San Francisco, California, 29 January-2 July 2021.
Sachdev, Darpun D; Chew Ng, Rilene; Sankaran, Madeline; Ernst, Alexandra; Hernandez, Katherine T; Servellita, Venice; Sotomayor-Gonzalez, Alicia; Stoltey, Juliet; Cohen, Stephanie E; Nguyen, Trang Quyen; Chiu, Charles Y; Philip, Susan.
  • Sachdev DD; San Francisco Department of Public Health, San Francisco, California, USA.
  • Chew Ng R; San Francisco Department of Public Health, San Francisco, California, USA.
  • Sankaran M; US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Ernst A; San Francisco Department of Public Health, San Francisco, California, USA.
  • Hernandez KT; Institute for Global Health Sciences, University of California, San Francisco, San Francisco, California, USA.
  • Servellita V; San Francisco Department of Public Health, San Francisco, California, USA.
  • Sotomayor-Gonzalez A; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Stoltey J; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA.
  • Cohen SE; San Francisco Department of Public Health, San Francisco, California, USA.
  • Nguyen TQ; San Francisco Department of Public Health, San Francisco, California, USA.
  • Chiu CY; San Francisco Department of Public Health, San Francisco, California, USA.
  • Philip S; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California, USA.
Clin Infect Dis ; 75(1): e267-e275, 2022 08 24.
Article in English | MEDLINE | ID: covidwho-1701610
ABSTRACT

BACKGROUND:

The extent to which vaccinated persons diagnosed with coronavirus disease 2019 (COVID-19) can transmit to other vaccinated and unvaccinated persons is unclear.

METHODS:

Using data from the San Francisco Department of Public Health, this report describes outcomes of household contact tracing during 29 January-2 July 2021, where fully vaccinated patients with COVID-19 were the index case in the household.

RESULTS:

Among 248 fully vaccinated patients with breakthrough infections, 203 (82%) were symptomatic and 105 were identified as the index patient within their household. Among 179 named household contacts, 71 (40%) contacts tested, over half (56%) were fully vaccinated and the secondary attack rate was 28%. Overall transmission from a symptomatic fully vaccinated patient with breakthrough infection to household contacts was suspected in 14 of 105 (13%) of households. Viral genomic sequencing of samples from 44% of fully vaccinated patients showed that 82% of those sequenced were infected by a variant of concern or interest and 77% by a variant carrying mutation(s) associated with resistance to neutralizing antibodies.

CONCLUSIONS:

Transmission from fully vaccinated symptomatic index patients to vaccinated and unvaccinated household contacts can occur. Indoor face masking and timely testing of all household contacts should be considered when a household member receives a positive test result in order to identify and interrupt transmission chains.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Contact Tracing / COVID-19 Type of study: Observational study Topics: Vaccines / Variants Limits: Humans Country/Region as subject: North America Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Contact Tracing / COVID-19 Type of study: Observational study Topics: Vaccines / Variants Limits: Humans Country/Region as subject: North America Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid