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What Is the Antibody Response and Role in Conferring Natural Immunity After SARS-CoV-2 Infection? Rapid, Living Practice Points From the American College of Physicians (Version 2).
Qaseem, Amir; Yost, Jennifer; Etxeandia-Ikobaltzeta, Itziar; Forciea, Mary Ann; Abraham, George M; Miller, Matthew C; Obley, Adam J; Humphrey, Linda L; Akl, Elie A; Andrews, Rebecca; Dunn, Andrew; Haeme, Ray; Kansagara, Devan L; Tschanz, Mark P.
  • Qaseem A; American College of Physicians, Philadelphia, Pennsylvania (A.Q., I.E.).
  • Yost J; American College of Physicians, Philadelphia, and Villanova University, Villanova, Pennsylvania (J.Y.).
  • Etxeandia-Ikobaltzeta I; American College of Physicians, Philadelphia, Pennsylvania (A.Q., I.E.).
  • Forciea MA; Penn Medicine, Philadelphia, Pennsylvania (M.A.F.).
  • Abraham GM; University of Massachusetts Medical School/Saint Vincent Hospital, Worcester, Massachusetts (G.M.A.).
  • Miller MC; Penn Medicine Radnor, Radnor, Pennsylvania (M.C.M.).
  • Obley AJ; Portland Veterans Affairs Medical Center and Oregon Health & Science University, Portland, Oregon (A.J.O., L.L.H.).
  • Humphrey LL; Portland Veterans Affairs Medical Center and Oregon Health & Science University, Portland, Oregon (A.J.O., L.L.H.).
Ann Intern Med ; 175(4): 556-565, 2022 04.
Article in English | MEDLINE | ID: covidwho-1702163
ABSTRACT
DESCRIPTION The Scientific Medical Policy Committee (SMPC) of the American College of Physicians (ACP) developed these living, rapid practice points to summarize the current best available evidence on the antibody response to SARS-CoV-2 infection and protection against reinfection with SARS-CoV-2. This is version 2 of the ACP practice points, which serves to update version 1, published on 16 March 2021. These practice points do not evaluate vaccine-acquired immunity or cellular immunity.

METHODS:

The SMPC developed this version of the living, rapid practice points based on an updated living, rapid, systematic review conducted by the Portland VA Research Foundation and funded by the Agency for Healthcare Research and Quality. PRACTICE POINT 1 Do not use SARS-CoV-2 antibody tests for the diagnosis of SARS-CoV-2 infection. PRACTICE POINT 2 Do not use SARS-CoV-2 antibody tests to predict the degree or duration of natural immunity conferred by antibodies against reinfection, including natural immunity against different variants. RETIREMENT FROM LIVING STATUS Although natural immunity remains a topic of scientific interest, this topic is being retired from living status given the availability of effective vaccines for SARS-CoV-2 and widespread recommendations for and prevalence of their use. Currently, vaccination is the best clinical recommendation for preventing infection, reinfection, and serious illness from SARS-CoV-2 and its variants.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Physicians / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Vaccines / Variants Limits: Humans Language: English Journal: Ann Intern Med Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Physicians / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Topics: Vaccines / Variants Limits: Humans Language: English Journal: Ann Intern Med Year: 2022 Document Type: Article