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SARS-CoV-2 vaccination washes away original antigenic sin.
Pillai, Shiv.
  • Pillai S; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA. Electronic address: pillai@helix.mgh.harvard.edu.
Trends Immunol ; 43(4): 271-273, 2022 04.
Article in English | MEDLINE | ID: covidwho-1702351
ABSTRACT
According to Röltgen and colleagues vaccination generates antibody breadth, whereas SARS-CoV-2 infection does not. Vaccination results in germinal center B cell responses and generates immunological breadth, with antibodies that bind viral variants. COVID-19 from SARS-CoV-2 infection does not induce germinal centers; it sustains immune imprinting, also known as 'original antigenic sin', and this results in limited immunological breadth.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines / Variants Limits: Humans Language: English Journal: Trends Immunol Journal subject: Allergy and Immunology Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines / Variants Limits: Humans Language: English Journal: Trends Immunol Journal subject: Allergy and Immunology Year: 2022 Document Type: Article