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Circulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients.
Ogata, Alana F; Cheng, Chi-An; Desjardins, Michaël; Senussi, Yasmeen; Sherman, Amy C; Powell, Megan; Novack, Lewis; Von, Salena; Li, Xiaofang; Baden, Lindsey R; Walt, David R.
  • Ogata AF; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Cheng CA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.
  • Desjardins M; Harvard Medical School, Boston, Massachusetts, USA.
  • Senussi Y; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Sherman AC; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA.
  • Powell M; Harvard Medical School, Boston, Massachusetts, USA.
  • Novack L; Harvard Medical School, Boston, Massachusetts, USA.
  • Von S; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Li X; Division of Infectious Diseases, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
  • Baden LR; Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Walt DR; Harvard Medical School, Boston, Massachusetts, USA.
Clin Infect Dis ; 74(4): 715-718, 2022 03 01.
Article in English | MEDLINE | ID: covidwho-1702854
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins were measured in longitudinal plasma samples collected from 13 participants who received two doses of mRNA-1273 vaccine. Eleven of 13 participants showed detectable levels of SARS-CoV-2 protein as early as day 1 after first vaccine injection. Clearance of detectable SARS-CoV-2 protein correlated with production of immunoglobulin G (IgG) and immunoglobulin A (IgA).
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / 2019-nCoV Vaccine mRNA-1273 Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / 2019-nCoV Vaccine mRNA-1273 Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid