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T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals.
Naranbhai, Vivek; Nathan, Anusha; Kaseke, Clarety; Berrios, Cristhian; Khatri, Ashok; Choi, Shawn; Getz, Matthew A; Tano-Menka, Rhoda; Ofoman, Onosereme; Gayton, Alton; Senjobe, Fernando; Zhao, Zezhou; St Denis, Kerri J; Lam, Evan C; Carrington, Mary; Garcia-Beltran, Wilfredo F; Balazs, Alejandro B; Walker, Bruce D; Iafrate, A John; Gaiha, Gaurav D.
  • Naranbhai V; Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Dana-Farber Cancer Institute, Boston, MA 02215, USA; Center for the AIDS Programme of Research in South Africa, Durban 4001, South Africa. Electronic address: vnaranbhai@mgh.harvard.edu.
  • Nathan A; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Program in Health Sciences & Technology, Harvard Medical School, Massachusetts Institute of Technology, Boston, MA 02115, USA.
  • Kaseke C; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Berrios C; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Khatri A; Massachusetts General Hospital Endocrine Division and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA.
  • Choi S; Massachusetts General Hospital Endocrine Division and Department of Medicine, Harvard Medical School, Boston, MA 02114, USA.
  • Getz MA; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Tano-Menka R; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Ofoman O; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Gayton A; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Senjobe F; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Zhao Z; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Program in Health Sciences & Technology, Harvard Medical School, Massachusetts Institute of Technology, Boston, MA 02115, USA.
  • St Denis KJ; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Lam EC; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Carrington M; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Basic Science Program, Frederick National Laboratory for Cancer Research in the Laboratory of Integrative Cancer Immunology, National Cancer Institute, Bethesda, MD 20892, USA.
  • Garcia-Beltran WF; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Balazs AB; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA.
  • Walker BD; Center for the AIDS Programme of Research in South Africa, Durban 4001, South Africa; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; The Broad Institute, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Institute for Medical Engineering and S
  • Iafrate AJ; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Gaiha GD; Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Division of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address: ggaiha@mgh.harvard.edu.
Cell ; 185(6): 1041-1051.e6, 2022 03 17.
Article in English | MEDLINE | ID: covidwho-1703106
ABSTRACT
The SARS-CoV-2 Omicron variant (B.1.1.529) contains mutations that mediate escape from antibody responses, although the extent to which these substitutions in spike and non-spike proteins affect T cell recognition is unknown. In this study, we show that T cell responses in individuals with prior infection, vaccination, both prior infection and vaccination, and boosted vaccination are largely preserved to Omicron spike and non-spike proteins. However, we also identify a subset of individuals (∼21%) with a >50% reduction in T cell reactivity to the Omicron spike. Evaluation of functional CD4+ and CD8+ memory T cell responses confirmed these findings and revealed that reduced recognition to Omicron spike is primarily observed within the CD8+ T cell compartment potentially due to escape from HLA binding. Booster vaccination enhanced T cell responses to Omicron spike. In contrast to neutralizing immunity, these findings suggest preservation of T cell responses to the Omicron variant, although with reduced reactivity in some individuals.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Vaccines / Variants Language: English Journal: Cell Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Topics: Vaccines / Variants Language: English Journal: Cell Year: 2022 Document Type: Article