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Therapeutic potentials of CRISPR-Cas genome editing technology in human viral infections.
Najafi, Sajad; Tan, Shing Cheng; Aghamiri, Shahin; Raee, Pourya; Ebrahimi, Zahra; Jahromi, Zahra Kargar; Rahmati, Yazdan; Sadri Nahand, Javid; Piroozmand, Ahmad; Jajarmi, Vahid; Mirzaei, Hamed.
  • Najafi S; Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Tan SC; UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
  • Aghamiri S; Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Raee P; Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Ebrahimi Z; Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Jahromi ZK; Central Research Laboratory, Jahrom University of Medical Sciences, Jahrom, Iran.
  • Rahmati Y; Department of Medical Genetics and Molecular Biology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Sadri Nahand J; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Piroozmand A; Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran.
  • Jajarmi V; Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: v.jajarmi@gmail.com.
  • Mirzaei H; Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran; Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. Electronic address: mirzaei-h@kaums.ac.ir.
Biomed Pharmacother ; 148: 112743, 2022 Apr.
Article in English | MEDLINE | ID: covidwho-1803592
ABSTRACT
Viral infections are a common cause of morbidity worldwide. The emergence of Coronavirus Disease 2019 (COVID-19) has led to more attention to viral infections and finding novel therapeutics. The CRISPR-Cas9 system has been recently proposed as a potential therapeutic tool for the treatment of viral diseases. Here, we review the research progress in the use of CRISPR-Cas technology for treating viral infections, as well as the strategies for improving the delivery of this gene-editing tool in vivo. Key challenges that hinder the widespread clinical application of CRISPR-Cas9 technology are also discussed, and several possible directions for future research are proposed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Diseases / Genetic Therapy / CRISPR-Cas Systems / Gene Editing Type of study: Prognostic study Limits: Humans Language: English Journal: Biomed Pharmacother Year: 2022 Document Type: Article Affiliation country: J.biopha.2022.112743

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Diseases / Genetic Therapy / CRISPR-Cas Systems / Gene Editing Type of study: Prognostic study Limits: Humans Language: English Journal: Biomed Pharmacother Year: 2022 Document Type: Article Affiliation country: J.biopha.2022.112743