Therapeutic potentials of CRISPR-Cas genome editing technology in human viral infections.
Biomed Pharmacother
; 148: 112743, 2022 Apr.
Article
in English
| MEDLINE | ID: covidwho-1803592
ABSTRACT
Viral infections are a common cause of morbidity worldwide. The emergence of Coronavirus Disease 2019 (COVID-19) has led to more attention to viral infections and finding novel therapeutics. The CRISPR-Cas9 system has been recently proposed as a potential therapeutic tool for the treatment of viral diseases. Here, we review the research progress in the use of CRISPR-Cas technology for treating viral infections, as well as the strategies for improving the delivery of this gene-editing tool in vivo. Key challenges that hinder the widespread clinical application of CRISPR-Cas9 technology are also discussed, and several possible directions for future research are proposed.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Virus Diseases
/
Genetic Therapy
/
CRISPR-Cas Systems
/
Gene Editing
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Biomed Pharmacother
Year:
2022
Document Type:
Article
Affiliation country:
J.biopha.2022.112743
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