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Variants of Concern Are Overrepresented Among Postvaccination Breakthrough Infections of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Washington State.
McEwen, Abbye E; Cohen, Seth; Bryson-Cahn, Chloe; Liu, Catherine; Pergam, Steven A; Lynch, John; Schippers, Adrienne; Strand, Kathy; Whimbey, Estella; Mani, Nandita S; Zelikoff, Allison J; Makarewicz, Vanessa A; Brown, Elizabeth R; Bakhash, Shah A Mohamed; Baker, Noah R; Castor, Jared; Livingston, Robert J; Huang, Meei-Li; Jerome, Keith R; Greninger, Alexander L; Roychoudhury, Pavitra.
  • McEwen AE; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
  • Cohen S; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.
  • Bryson-Cahn C; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.
  • Liu C; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Pergam SA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Lynch J; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.
  • Schippers A; Department of Infection Prevention and Employee Health, University of Washington Medical Center, Seattle, Washington, USA.
  • Strand K; Department of Infection Prevention and Employee Health, University of Washington Medical Center, Seattle, Washington, USA.
  • Whimbey E; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.
  • Mani NS; Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington, USA.
  • Zelikoff AJ; Harborview Medical Center, University of Washington, Seattle, Washington, USA.
  • Makarewicz VA; Harborview Medical Center, University of Washington, Seattle, Washington, USA.
  • Brown ER; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Bakhash SAM; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
  • Baker NR; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
  • Castor J; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
  • Livingston RJ; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
  • Huang ML; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
  • Jerome KR; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
  • Greninger AL; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Roychoudhury P; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
Clin Infect Dis ; 74(6): 1089-1092, 2022 03 23.
Article in English | MEDLINE | ID: covidwho-1703666
ABSTRACT
Across 20 vaccine breakthrough cases detected at our institution, all 20 (100%) infections were due to variants of concern (VOCs) and had a median Ct of 20.2 (IQR, 17.1-23.3). When compared with 5174 contemporaneous samples sequenced in our laboratory, VOCs were significantly enriched among breakthrough infections (P < .05).
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study Topics: Vaccines / Variants Limits: Humans Country/Region as subject: North America Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study Topics: Vaccines / Variants Limits: Humans Country/Region as subject: North America Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid