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A decoy mutant ACE2 designed to reduce COVID-19.
Maishan, Mazharul; Lim, Diana L; Zimmerman, Guy A; Matthay, Michael A.
  • Maishan M; Cardiovascular Research Institute, University of California at San Francisco, San Francisco, CA, USA.
  • Lim DL; Molecular Medicine Program, University of Utah Health, Salt Lake City, UT, USA.
  • Zimmerman GA; Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.
  • Matthay MA; Cardiovascular Research Institute, University of California at San Francisco, San Francisco, CA, USA; Departments of Medicine and Anesthesia, University of California at San Francisco, San Francisco, CA, USA. Electronic address: michael.matthay@ucsf.edu.
Trends Pharmacol Sci ; 43(9): 703-705, 2022 09.
Article in English | MEDLINE | ID: covidwho-1703950
ABSTRACT
The need for new coronavirus disease 2019 (COVID-19) therapeutic strategies continues, especially as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants emerge. Zhang and colleagues elegantly engineered a mutant angiotensin-converting enzyme 2 (ACE2) that competitively binds SARS-CoV-2 spike protein, reduces viral uptake by human lung cells, and ameliorates SARS-CoV-2-induced lung injury in mice expressing human ACE2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / Angiotensin-Converting Enzyme 2 / COVID-19 Topics: Variants Limits: Animals / Humans Language: English Journal: Trends Pharmacol Sci Year: 2022 Document Type: Article Affiliation country: J.tips.2022.02.010

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Spike Glycoprotein, Coronavirus / Angiotensin-Converting Enzyme 2 / COVID-19 Topics: Variants Limits: Animals / Humans Language: English Journal: Trends Pharmacol Sci Year: 2022 Document Type: Article Affiliation country: J.tips.2022.02.010