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Treatment of MIS-C in Children and Adolescents.
Mahmoud, Sanaa; El-Kalliny, Mostafa; Kotby, Alyaa; El-Ganzoury, Mona; Fouda, Eman; Ibrahim, Hanan.
  • Mahmoud S; Division of Allergy and Immunology, Department of Pediatrics, Ain Shams University, Cairo, Egypt.
  • El-Kalliny M; University of Pikeville, Kentucky College of Osteopathic Medicine, Pikeville, KY 41501 USA.
  • Kotby A; Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO 80309 USA.
  • El-Ganzoury M; Medical Scientist Training Program, University of Colorado Anschutz Medical School, Aurora, CO 80045 USA.
  • Fouda E; Division of Cardiology, Department of Pediatrics, Ain Shams University, Cairo, Egypt.
  • Ibrahim H; Division of Cardiology, Department of Pediatrics, Ain Shams University, Cairo, Egypt.
Curr Pediatr Rep ; 10(1): 1-10, 2022.
Article in English | MEDLINE | ID: covidwho-2316863
ABSTRACT
Purpose of Review Different treatment approaches have been described for the management of COVID-19-related multisystem inflammatory syndrome in children (MIS-C), the pathogenesis of which has not yet been fully elucidated. Here, we comprehensively review and summarize the recommendations and management strategies that have been published to date. Recent

Findings:

MIS-C patients are treated with different regimens, mostly revolving around the use of immunomodulatory medications, including IVIG and glucocorticoids as first-tier therapy. Refractoriness to IVIG and glucocorticoids warrants a step-up of immunomodulatory therapy to biologic agents such as anakinra, tocilizumab, and infliximab.

Summary:

We review the current evidence regarding the use of monotherapy versus combination therapy, as well as the current recommendations for assessing thrombotic risk and administering antiplatelet and anticoagulant therapy. We anticipate that future studies will provide evidence for management plans that maximize short- and long-term outcomes. Supplementary Information The online version contains supplementary material available at 10.1007/s40124-021-00259-4.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Curr Pediatr Rep Year: 2022 Document Type: Article Affiliation country: S40124-021-00259-4

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Curr Pediatr Rep Year: 2022 Document Type: Article Affiliation country: S40124-021-00259-4