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Crystal-reconstructed BiVO4 semiconductor photoelectrochemical sensor for ultra-sensitive tumor biomarker detection.
Li, Yang; Dai, Xianying; He, Lin; Bu, Yuyu; Ao, Jin-Ping.
  • Li Y; Key Laboratory of Wide Band-Gap Semiconductor Materials and Devices, School of Microelectronics, Xidian University, Xi'an, 710071, China. yybu@xidian.edu.cn.
  • Dai X; Key Laboratory of Wide Band-Gap Semiconductor Materials and Devices, School of Microelectronics, Xidian University, Xi'an, 710071, China. yybu@xidian.edu.cn.
  • He L; Shaanxi Provincial Cancer Hospital, Xi'an, 710061, China.
  • Bu Y; Key Laboratory of Wide Band-Gap Semiconductor Materials and Devices, School of Microelectronics, Xidian University, Xi'an, 710071, China. yybu@xidian.edu.cn.
  • Ao JP; Key Laboratory of Wide Band-Gap Semiconductor Materials and Devices, School of Microelectronics, Xidian University, Xi'an, 710071, China. yybu@xidian.edu.cn.
J Mater Chem B ; 10(6): 870-879, 2022 02 09.
Article in English | MEDLINE | ID: covidwho-1890289
ABSTRACT
In this study, we developed a crystal-reconstructed-BiVO4 aptamer photoelectrochemical (PEC) biosensor by a high-energy laser treatment technique. This biosensor achieves a limit of detection (LOD) (0.82 ag mL-1), linear detection range (1 ag mL-1 to 2 ng mL-1), and resolution ratio (∼18 molecules per mL) for prostate-specific antigen (PSA) tumor biomarker detection. Furthermore, reconstructed surface microstructure and oxygen vacancy doping energy formation after crystal reconstruction induce the stereo-hindrance effect and photogenerated hole energy is reduced during PSA target detection. In this case, a photocurrent inhibition phenomenon for PSA detection is noticed. Based on this photocurrent inversion phenomenon, some dysoxidizable nucleonic acid tumor (miRNA-21) and virus biomarkers (RdRp-COVID) can be detected with a LOD level of ∼10-16 M by linking the corresponding base paring probe on the surface of the crystal-reconstructed photoanode. In addition to high sensitivity, this PEC biosensor presents high detection specificity, stability, and accuracy in clinical verification. Thus, this crystal-reconstructed PEC biosensor shows application potential in the fields of multi-tumor or viral biomarker detection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Neoplasms Type of study: Diagnostic study / Prognostic study Limits: Humans / Male Language: English Journal: J Mater Chem B Year: 2022 Document Type: Article Affiliation country: D1tb02576g

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Neoplasms Type of study: Diagnostic study / Prognostic study Limits: Humans / Male Language: English Journal: J Mater Chem B Year: 2022 Document Type: Article Affiliation country: D1tb02576g