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SARS-CoV-2 Seroprevalence in Healthcare Workers before the Vaccination in Poland: Evolution from the First to the Second Pandemic Outbreak.
Korona-Glowniak, Izabela; Mielnik, Michal; Podgajna, Martyna; Grywalska, Ewelina; Hus, Marek; Matuska, Katarzyna; Wojtysiak-Duma, Beata; Duma, Dariusz; Glowniak, Andrzej; Malm, Anna.
  • Korona-Glowniak I; Department of Pharmaceutical Microbiology, Medical University of Lublin, 20-093 Lublin, Poland.
  • Mielnik M; Department of Hematooncology and Bone Marrow Transplantation, Medical University of Lublin, 20-081 Lublin, Poland.
  • Podgajna M; Department of Experimental Immunology, Medical University of Lublin, 20-093 Lublin, Poland.
  • Grywalska E; Department of Experimental Immunology, Medical University of Lublin, 20-093 Lublin, Poland.
  • Hus M; Department of Hematooncology and Bone Marrow Transplantation, Medical University of Lublin, 20-081 Lublin, Poland.
  • Matuska K; Department of Pharmaceutical Microbiology, Medical University of Lublin, 20-093 Lublin, Poland.
  • Wojtysiak-Duma B; Department of Laboratory Diagnostics, Medical University, 20-093 Lublin, Poland.
  • Duma D; Department of Laboratory Diagnostics, Medical University, 20-093 Lublin, Poland.
  • Glowniak A; Department of Cardiology, Medical University of Lublin, 20-093 Lublin, Poland.
  • Malm A; Clinical Department of Electrocardiology, SPSK-4 University Hospital, 20-090 Lublin, Poland.
Int J Environ Res Public Health ; 19(4)2022 02 17.
Article in English | MEDLINE | ID: covidwho-1704765
ABSTRACT
Healthcare workers (HCWs) are on the frontline, struggling with the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To describe recent or past infections, the serological assays enabled the assessment of the immune response developed in coronavirus disease (COVID-19) in the period when testing was hardly available. In this study, we investigated SARS-CoV-2 seroprevalence in HCWs in a Polish teaching hospital and the Regional Occupational Medicine Center after both the first and the second waves. ELISA-based tests for anti-SARS-CoV-2 IgA and IgG were used to determine immune response to SARS-CoV-2 in volunteer HCWs who worked in those institutions in May 2020 (208 participants aged 47.1 ± 12.5, 88% women) and in December 2020 (179 participants aged 45.2 ± 12.4, 86% woman). Risk factors for seropositivity were also assessed using a questionnaire filled out by all participants. We reported a significant increase in seroprevalence after the second wave (22.9%) compared with the first outbreak (2.4%) (OR 12.1; 95%CI 4.6-31.3; p < 0.0001). An association between IgG seroprevalence and severity of infections was noted. Furthermore, we demonstrated that amongst medical personnel, nurses exhibited a proportionally higher SARS-CoV-2 seroprevalence. Moreover, given the high seroprevalence in non-clinical group of HCWs, we suggest that community transmission can play a superior role to workplace exposure.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Risk factors Topics: Vaccines Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Year: 2022 Document Type: Article Affiliation country: Ijerph19042319

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Risk factors Topics: Vaccines Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Year: 2022 Document Type: Article Affiliation country: Ijerph19042319