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SARS-CoV-2 Viral RNA Is Detected in the Bone Marrow in Post-Mortem Samples Using RT-LAMP.
Jurek, Tomasz; Rorat, Marta; Szleszkowski, Lukasz; Tokarski, Miron; Pielka, Izabela; Malodobra-Mazur, Malgorzata.
  • Jurek T; Department of Forensic Medicine, Wroclaw Medical University, 50-345 Wroclaw, Poland.
  • Rorat M; Department of Forensic Medicine, Wroclaw Medical University, 50-345 Wroclaw, Poland.
  • Szleszkowski L; Department of Forensic Medicine, Wroclaw Medical University, 50-345 Wroclaw, Poland.
  • Tokarski M; Genomtec Inc., Bierutowska Street 57-59, 51-317 Wroclaw, Poland.
  • Pielka I; Genomtec Inc., Bierutowska Street 57-59, 51-317 Wroclaw, Poland.
  • Malodobra-Mazur M; Department of Forensic Medicine, Wroclaw Medical University, 50-345 Wroclaw, Poland.
Diagnostics (Basel) ; 12(2)2022 Feb 17.
Article in English | MEDLINE | ID: covidwho-1705222
ABSTRACT
Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2019, viral RNA has been detected in several different human tissues and organs. This study reports the detection of SARS-CoV-2 RNA in the bone marrow. Post-mortem samples were taken in a sterile manner during two forensic autopsies from the nasopharyngeal region, vitreous humor, cerebrospinal fluid, and bone marrow. SARS-CoV-2 was subsequently diagnosed via Genomtec® SARS-CoV-2 EvaGreen® RT-LAMP CE-IVD Duo Kit. In both postmortem patients, SARS-CoV-2 RNA was detected in bone marrow samples. However, both the vitreous humor and cerebrospinal fluid from the same patients gave negative results using the same test system. The evidence of viral RNA in the bone marrow, along with other reports supports the thesis that SARS-CoV-2 infections are systemic in nature, the consequences of which would profoundly influence both the testing and survival of patients.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Diagnostics12020515

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Prognostic study Language: English Year: 2022 Document Type: Article Affiliation country: Diagnostics12020515